node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARF1 | CLTCL1 | ENSGGOP00000010983 | ENSGGOP00000024160 | ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. | Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. | 0.709 |
ARF1 | HERC1 | ENSGGOP00000010983 | ENSGGOP00000029910 | ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. | 0.554 |
BIRC6 | G3QY09_GORGO | ENSGGOP00000049108 | ENSGGOP00000007729 | Baculoviral IAP repeat containing 6. | Protein inhibitor of activated STAT 4. | 0.550 |
BIRC6 | HERC1 | ENSGGOP00000049108 | ENSGGOP00000029910 | Baculoviral IAP repeat containing 6. | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. | 0.534 |
BIRC6 | MYCBP2 | ENSGGOP00000049108 | ENSGGOP00000010567 | Baculoviral IAP repeat containing 6. | MYC binding protein 2. | 0.583 |
BIRC6 | RNF8 | ENSGGOP00000049108 | ENSGGOP00000014628 | Baculoviral IAP repeat containing 6. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.437 |
BRCA1 | G3QY09_GORGO | ENSGGOP00000023921 | ENSGGOP00000007729 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Protein inhibitor of activated STAT 4. | 0.760 |
BRCA1 | HERC1 | ENSGGOP00000023921 | ENSGGOP00000029910 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. | 0.481 |
BRCA1 | RNF8 | ENSGGOP00000023921 | ENSGGOP00000014628 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.802 |
CLTCL1 | ARF1 | ENSGGOP00000024160 | ENSGGOP00000010983 | Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. | ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. | 0.709 |
CLTCL1 | HERC1 | ENSGGOP00000024160 | ENSGGOP00000029910 | Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. | 0.506 |
G3QH38_GORGO | HERC1 | ENSGGOP00000001657 | ENSGGOP00000029910 | Neuralized E3 ubiquitin protein ligase 4. | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. | 0.478 |
G3QY09_GORGO | BIRC6 | ENSGGOP00000007729 | ENSGGOP00000049108 | Protein inhibitor of activated STAT 4. | Baculoviral IAP repeat containing 6. | 0.550 |
G3QY09_GORGO | BRCA1 | ENSGGOP00000007729 | ENSGGOP00000023921 | Protein inhibitor of activated STAT 4. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.760 |
G3QY09_GORGO | HERC1 | ENSGGOP00000007729 | ENSGGOP00000029910 | Protein inhibitor of activated STAT 4. | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. | 0.538 |
G3QY09_GORGO | RNF8 | ENSGGOP00000007729 | ENSGGOP00000014628 | Protein inhibitor of activated STAT 4. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.806 |
G3R3H2_GORGO | HERC1 | ENSGGOP00000009799 | ENSGGOP00000029910 | KIAA1109. | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. | 0.668 |
HERC1 | ARF1 | ENSGGOP00000029910 | ENSGGOP00000010983 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. | ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. | 0.554 |
HERC1 | BIRC6 | ENSGGOP00000029910 | ENSGGOP00000049108 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. | Baculoviral IAP repeat containing 6. | 0.534 |
HERC1 | BRCA1 | ENSGGOP00000029910 | ENSGGOP00000023921 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.481 |