node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APEX1 | LIG3 | ENSGGOP00000044042 | ENSGGOP00000019141 | DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break w [...] | DNA ligase. | 0.875 |
APEX1 | PARP1 | ENSGGOP00000044042 | ENSGGOP00000025582 | DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break w [...] | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.848 |
APEX1 | PNKP | ENSGGOP00000044042 | ENSGGOP00000009949 | DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break w [...] | Polynucleotide kinase 3'-phosphatase. | 0.749 |
APEX1 | POLB | ENSGGOP00000044042 | ENSGGOP00000027997 | DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break w [...] | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.980 |
APEX1 | TDP1 | ENSGGOP00000044042 | ENSGGOP00000035137 | DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break w [...] | Tyrosyl-DNA phosphodiesterase 1. | 0.719 |
APEX1 | XRCC1 | ENSGGOP00000044042 | ENSGGOP00000031065 | DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break w [...] | X-ray repair cross complementing 1. | 0.967 |
APEX1 | XRCC5 | ENSGGOP00000044042 | ENSGGOP00000011192 | DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break w [...] | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. | 0.536 |
APEX1 | XRCC6 | ENSGGOP00000044042 | ENSGGOP00000015496 | DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break w [...] | X-ray repair cross complementing 6. | 0.446 |
APLF | LIG3 | ENSGGOP00000028711 | ENSGGOP00000019141 | Aprataxin and PNKP like factor. | DNA ligase. | 0.904 |
APLF | PARP1 | ENSGGOP00000028711 | ENSGGOP00000025582 | Aprataxin and PNKP like factor. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.887 |
APLF | PNKP | ENSGGOP00000028711 | ENSGGOP00000009949 | Aprataxin and PNKP like factor. | Polynucleotide kinase 3'-phosphatase. | 0.664 |
APLF | POLB | ENSGGOP00000028711 | ENSGGOP00000027997 | Aprataxin and PNKP like factor. | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.862 |
APLF | TDP1 | ENSGGOP00000028711 | ENSGGOP00000035137 | Aprataxin and PNKP like factor. | Tyrosyl-DNA phosphodiesterase 1. | 0.814 |
APLF | XRCC1 | ENSGGOP00000028711 | ENSGGOP00000031065 | Aprataxin and PNKP like factor. | X-ray repair cross complementing 1. | 0.973 |
APLF | XRCC5 | ENSGGOP00000028711 | ENSGGOP00000011192 | Aprataxin and PNKP like factor. | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. | 0.983 |
APLF | XRCC6 | ENSGGOP00000028711 | ENSGGOP00000015496 | Aprataxin and PNKP like factor. | X-ray repair cross complementing 6. | 0.968 |
LIG3 | APEX1 | ENSGGOP00000019141 | ENSGGOP00000044042 | DNA ligase. | DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break w [...] | 0.875 |
LIG3 | APLF | ENSGGOP00000019141 | ENSGGOP00000028711 | DNA ligase. | Aprataxin and PNKP like factor. | 0.904 |
LIG3 | PARP1 | ENSGGOP00000019141 | ENSGGOP00000025582 | DNA ligase. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.876 |
LIG3 | PNKP | ENSGGOP00000019141 | ENSGGOP00000009949 | DNA ligase. | Polynucleotide kinase 3'-phosphatase. | 0.965 |