TSPAN2 protein (Pan paniscus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

TSPAN2

Tetraspanin. (228 aa)

Predicted Functional Partners:

VIPR1

0.904

TMEM86A

0.904

GET3

0.879

ADAMTS3

0.835

PTGS1

0.782

CD63

0.572

GDF15

0.571

HOXD3

0.537

CX3CL1

0.507

ITGB1

0.496

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS3	CX3CL1	ENSPPAP00000035880	ENSPPAP00000026840	ADAM metallopeptidase with thrombospondin type 1 motif 3.	C-X3-C motif chemokine ligand 1.	0.797
ADAMTS3	GDF15	ENSPPAP00000035880	ENSPPAP00000031141	ADAM metallopeptidase with thrombospondin type 1 motif 3.	Growth differentiation factor 15.	0.779
ADAMTS3	GET3	ENSPPAP00000035880	ENSPPAP00000039578	ADAM metallopeptidase with thrombospondin type 1 motif 3.	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	0.881
ADAMTS3	HOXD3	ENSPPAP00000035880	ENSPPAP00000017261	ADAM metallopeptidase with thrombospondin type 1 motif 3.	Homeobox D3.	0.517
ADAMTS3	PTGS1	ENSPPAP00000035880	ENSPPAP00000008664	ADAM metallopeptidase with thrombospondin type 1 motif 3.	Prostaglandin-endoperoxide synthase 1.	0.736
ADAMTS3	TMEM86A	ENSPPAP00000035880	ENSPPAP00000013991	ADAM metallopeptidase with thrombospondin type 1 motif 3.	Transmembrane protein 86A.	0.880
ADAMTS3	TSPAN2	ENSPPAP00000035880	ENSPPAP00000010316	ADAM metallopeptidase with thrombospondin type 1 motif 3.	Tetraspanin.	0.835
ADAMTS3	VIPR1	ENSPPAP00000035880	ENSPPAP00000003790	ADAM metallopeptidase with thrombospondin type 1 motif 3.	Vasoactive intestinal peptide receptor 1; Belongs to the G-protein coupled receptor 2 family.	0.879
CD63	ITGB1	ENSPPAP00000035325	ENSPPAP00000031658	Tetraspanin.	Integrin beta; Belongs to the integrin beta chain family.	0.913
CD63	TSPAN2	ENSPPAP00000035325	ENSPPAP00000010316	Tetraspanin.	Tetraspanin.	0.572
CX3CL1	ADAMTS3	ENSPPAP00000026840	ENSPPAP00000035880	C-X3-C motif chemokine ligand 1.	ADAM metallopeptidase with thrombospondin type 1 motif 3.	0.797
CX3CL1	GDF15	ENSPPAP00000026840	ENSPPAP00000031141	C-X3-C motif chemokine ligand 1.	Growth differentiation factor 15.	0.740
CX3CL1	GET3	ENSPPAP00000026840	ENSPPAP00000039578	C-X3-C motif chemokine ligand 1.	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	0.604
CX3CL1	TMEM86A	ENSPPAP00000026840	ENSPPAP00000013991	C-X3-C motif chemokine ligand 1.	Transmembrane protein 86A.	0.591
CX3CL1	TSPAN2	ENSPPAP00000026840	ENSPPAP00000010316	C-X3-C motif chemokine ligand 1.	Tetraspanin.	0.507
CX3CL1	VIPR1	ENSPPAP00000026840	ENSPPAP00000003790	C-X3-C motif chemokine ligand 1.	Vasoactive intestinal peptide receptor 1; Belongs to the G-protein coupled receptor 2 family.	0.649
GDF15	ADAMTS3	ENSPPAP00000031141	ENSPPAP00000035880	Growth differentiation factor 15.	ADAM metallopeptidase with thrombospondin type 1 motif 3.	0.779
GDF15	CX3CL1	ENSPPAP00000031141	ENSPPAP00000026840	Growth differentiation factor 15.	C-X3-C motif chemokine ligand 1.	0.740
GDF15	GET3	ENSPPAP00000031141	ENSPPAP00000039578	Growth differentiation factor 15.	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	0.620
GDF15	HOXD3	ENSPPAP00000031141	ENSPPAP00000017261	Growth differentiation factor 15.	Homeobox D3.	0.467