STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)    
Predicted Functional Partners:
ATF6
Activating transcription factor 6.
   
 0.989
ATF4
Activating transcription factor 4.
   
 0.986
XBP1
BZIP domain-containing protein.
   
 0.976
BCL2L11
Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.
     
 0.975
BCL2
BCL2 apoptosis regulator.
   
 0.954
ATF6B
Activating transcription factor 6 beta.
   
 0.954
ATF3
Activating transcription factor 3.
   
 0.952
NFE2L2
Nuclear factor, erythroid 2 like 2.
   
 0.943
MAPK14
Mitogen-activated protein kinase.
   
 0.941
MAPK11
Mitogen-activated protein kinase.
   
 0.932
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.