node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F10 | F2 | ENSPPAP00000023740 | ENSPPAP00000037534 | Coagulation factor X. | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | 0.991 |
F10 | F3 | ENSPPAP00000023740 | ENSPPAP00000019759 | Coagulation factor X. | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. | 0.978 |
F10 | F7 | ENSPPAP00000023740 | ENSPPAP00000033219 | Coagulation factor X. | Coagulation factor VII; Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium (By similarity). Belongs to the peptidase S1 family. | 0.987 |
F10 | F8 | ENSPPAP00000023740 | ENSPPAP00000020588 | Coagulation factor X. | Coagulation factor VIII; Belongs to the multicopper oxidase family. | 0.941 |
F10 | F9 | ENSPPAP00000023740 | ENSPPAP00000034098 | Coagulation factor X. | Coagulation factor IX. | 0.975 |
F10 | GGCX | ENSPPAP00000023740 | ENSPPAP00000016388 | Coagulation factor X. | Gamma-glutamyl carboxylase. | 0.659 |
F10 | SERPINC1 | ENSPPAP00000023740 | ENSPPAP00000039928 | Coagulation factor X. | Serpin family C member 1; Belongs to the serpin family. | 0.997 |
F10 | TFPI | ENSPPAP00000023740 | ENSPPAP00000017323 | Coagulation factor X. | Tissue factor pathway inhibitor. | 0.994 |
F10 | THBD | ENSPPAP00000023740 | ENSPPAP00000004311 | Coagulation factor X. | Thrombomodulin. | 0.693 |
F2 | F10 | ENSPPAP00000037534 | ENSPPAP00000023740 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Coagulation factor X. | 0.991 |
F2 | F3 | ENSPPAP00000037534 | ENSPPAP00000019759 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. | 0.916 |
F2 | F7 | ENSPPAP00000037534 | ENSPPAP00000033219 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Coagulation factor VII; Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium (By similarity). Belongs to the peptidase S1 family. | 0.881 |
F2 | F8 | ENSPPAP00000037534 | ENSPPAP00000020588 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Coagulation factor VIII; Belongs to the multicopper oxidase family. | 0.926 |
F2 | F9 | ENSPPAP00000037534 | ENSPPAP00000034098 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Coagulation factor IX. | 0.885 |
F2 | GGCX | ENSPPAP00000037534 | ENSPPAP00000016388 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Gamma-glutamyl carboxylase. | 0.859 |
F2 | SERPINC1 | ENSPPAP00000037534 | ENSPPAP00000039928 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Serpin family C member 1; Belongs to the serpin family. | 0.999 |
F2 | TFPI | ENSPPAP00000037534 | ENSPPAP00000017323 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Tissue factor pathway inhibitor. | 0.749 |
F2 | THBD | ENSPPAP00000037534 | ENSPPAP00000004311 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Thrombomodulin. | 0.998 |
F3 | F10 | ENSPPAP00000019759 | ENSPPAP00000023740 | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. | Coagulation factor X. | 0.978 |
F3 | F2 | ENSPPAP00000019759 | ENSPPAP00000037534 | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | 0.916 |