STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HTR65-hydroxytryptamine receptor 6; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (By similarity). (440 aa)    
Predicted Functional Partners:
GNAS
GNAS isoform 19.
    
 0.988
HTR7
HTR7 isoform 2; Belongs to the G-protein coupled receptor 1 family.
     
0.941
HTR4
5-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family.
     
0.930
POMC
Proopiomelanocortin.
    
 0.924
ADCYAP1
Adenylate cyclase activating polypeptide 1.
    
 0.919
LOC104003639
Guanine nucleotide-binding protein G(s) subunit alpha.
    
  0.917
GCG
GCG isoform 1.
     
  0.904
TSHB
Thyroid stimulating hormone subunit beta.
     
  0.902
FSHB
Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs.
   
 
  0.902
GIP
Gastric inhibitory polypeptide.
    
  0.902
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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