node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKR1C2 | AKR1C3 | ENSPTRP00000061845 | ENSPTRP00000078798 | Aldo-keto reductase family 1 member C2. | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | 0.985 |
AKR1C2 | AKR1D1 | ENSPTRP00000061845 | ENSPTRP00000033814 | Aldo-keto reductase family 1 member C2. | Aldo-keto reductase family 1 member D1. | 0.770 |
AKR1C2 | CBR1 | ENSPTRP00000061845 | ENSPTRP00000023898 | Aldo-keto reductase family 1 member C2. | Carbonyl reductase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.441 |
AKR1C2 | HSD17B3 | ENSPTRP00000061845 | ENSPTRP00000073561 | Aldo-keto reductase family 1 member C2. | Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.437 |
AKR1C2 | HSD3B2 | ENSPTRP00000061845 | ENSPTRP00000051923 | Aldo-keto reductase family 1 member C2. | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; Belongs to the 3-beta-HSD family. | 0.519 |
AKR1C2 | SRD5A1 | ENSPTRP00000061845 | ENSPTRP00000028677 | Aldo-keto reductase family 1 member C2. | 3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. | 0.940 |
AKR1C3 | AKR1C2 | ENSPTRP00000078798 | ENSPTRP00000061845 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Aldo-keto reductase family 1 member C2. | 0.985 |
AKR1C3 | AKR1D1 | ENSPTRP00000078798 | ENSPTRP00000033814 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Aldo-keto reductase family 1 member D1. | 0.979 |
AKR1C3 | CBR1 | ENSPTRP00000078798 | ENSPTRP00000023898 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Carbonyl reductase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.952 |
AKR1C3 | CYP17A1 | ENSPTRP00000078798 | ENSPTRP00000069568 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.966 |
AKR1C3 | CYP19A1 | ENSPTRP00000078798 | ENSPTRP00000012092 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.944 |
AKR1C3 | HSD17B1 | ENSPTRP00000078798 | ENSPTRP00000062753 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Estradiol 17-beta-dehydrogenase 1; Favors the reduction of estrogens and androgens. Also has 20- alpha-HSD activity. Uses preferentially NADH; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.957 |
AKR1C3 | HSD17B2 | ENSPTRP00000078798 | ENSPTRP00000014332 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.968 |
AKR1C3 | HSD17B3 | ENSPTRP00000078798 | ENSPTRP00000073561 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.966 |
AKR1C3 | HSD3B2 | ENSPTRP00000078798 | ENSPTRP00000051923 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; Belongs to the 3-beta-HSD family. | 0.962 |
AKR1C3 | SRD5A1 | ENSPTRP00000078798 | ENSPTRP00000028677 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | 3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. | 0.956 |
AKR1D1 | AKR1C2 | ENSPTRP00000033814 | ENSPTRP00000061845 | Aldo-keto reductase family 1 member D1. | Aldo-keto reductase family 1 member C2. | 0.770 |
AKR1D1 | AKR1C3 | ENSPTRP00000033814 | ENSPTRP00000078798 | Aldo-keto reductase family 1 member D1. | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II). | 0.979 |
AKR1D1 | CYP17A1 | ENSPTRP00000033814 | ENSPTRP00000069568 | Aldo-keto reductase family 1 member D1. | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.922 |
AKR1D1 | CYP19A1 | ENSPTRP00000033814 | ENSPTRP00000012092 | Aldo-keto reductase family 1 member D1. | Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.910 |