node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DCN | EGFR | ENSPTRP00000008989 | ENSPTRP00000069741 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Receptor protein-tyrosine kinase. | 0.985 |
DCN | ERBB2 | ENSPTRP00000008989 | ENSPTRP00000069840 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Receptor protein-tyrosine kinase. | 0.953 |
DCN | IGF1 | ENSPTRP00000008989 | ENSPTRP00000067917 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Insulin-like growth factor 1 (Somatomedin C). | 0.968 |
DCN | LUM | ENSPTRP00000008989 | ENSPTRP00000008987 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | LUM isoform 1. | 0.951 |
DCN | MET | ENSPTRP00000008989 | ENSPTRP00000083162 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.970 |
DCN | TGFB1 | ENSPTRP00000008989 | ENSPTRP00000018930 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.992 |
DCN | TGFB2 | ENSPTRP00000008989 | ENSPTRP00000003339 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.966 |
DCN | TGFB3 | ENSPTRP00000008989 | ENSPTRP00000011150 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.958 |
DCN | TLR2 | ENSPTRP00000008989 | ENSPTRP00000028379 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.967 |
DCN | TLR4 | ENSPTRP00000008989 | ENSPTRP00000036398 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Toll-like receptor 4; Belongs to the Toll-like receptor family. | 0.958 |
EGFR | DCN | ENSPTRP00000069741 | ENSPTRP00000008989 | Receptor protein-tyrosine kinase. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.985 |
EGFR | ERBB2 | ENSPTRP00000069741 | ENSPTRP00000069840 | Receptor protein-tyrosine kinase. | Receptor protein-tyrosine kinase. | 0.999 |
EGFR | IGF1 | ENSPTRP00000069741 | ENSPTRP00000067917 | Receptor protein-tyrosine kinase. | Insulin-like growth factor 1 (Somatomedin C). | 0.972 |
EGFR | MET | ENSPTRP00000069741 | ENSPTRP00000083162 | Receptor protein-tyrosine kinase. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.976 |
EGFR | TGFB1 | ENSPTRP00000069741 | ENSPTRP00000018930 | Receptor protein-tyrosine kinase. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.792 |
EGFR | TGFB2 | ENSPTRP00000069741 | ENSPTRP00000003339 | Receptor protein-tyrosine kinase. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.528 |
EGFR | TLR2 | ENSPTRP00000069741 | ENSPTRP00000028379 | Receptor protein-tyrosine kinase. | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.870 |
EGFR | TLR4 | ENSPTRP00000069741 | ENSPTRP00000036398 | Receptor protein-tyrosine kinase. | Toll-like receptor 4; Belongs to the Toll-like receptor family. | 0.528 |
ERBB2 | DCN | ENSPTRP00000069840 | ENSPTRP00000008989 | Receptor protein-tyrosine kinase. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.953 |
ERBB2 | EGFR | ENSPTRP00000069840 | ENSPTRP00000069741 | Receptor protein-tyrosine kinase. | Receptor protein-tyrosine kinase. | 0.999 |