node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APRT | HPRT1 | ENSPTRP00000014433 | ENSPTRP00000086770 | Adenine phosphoribosyltransferase. | Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). | 0.970 |
APRT | ITPA | ENSPTRP00000014433 | ENSPTRP00000022599 | Adenine phosphoribosyltransferase. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.989 |
APRT | PDE6D | ENSPTRP00000014433 | ENSPTRP00000022277 | Adenine phosphoribosyltransferase. | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...] | 0.900 |
ARL13B | ARL3 | ENSPTRP00000026120 | ENSPTRP00000082289 | ADP ribosylation factor like GTPase 13B. | ADP-ribosylation factor-like 3; Belongs to the small GTPase superfamily. Arf family. | 0.700 |
ARL13B | INPP5E | ENSPTRP00000026120 | ENSPTRP00000091349 | ADP ribosylation factor like GTPase 13B. | Phosphatidylinositol polyphosphate 5-phosphatase type IV; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate(PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Specific for lipid substrates, inactive towards water soluble inositol phosphates (By similarity). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity); Belongs to the inos [...] | 0.932 |
ARL13B | PDE6D | ENSPTRP00000026120 | ENSPTRP00000022277 | ADP ribosylation factor like GTPase 13B. | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...] | 0.938 |
ARL2 | CK820_G0042963 | ENSPTRP00000058328 | ENSPTRP00000069096 | ARL2-SNX15 isoform 1; Belongs to the small GTPase superfamily. Arf family. | RHEB isoform 3. | 0.427 |
ARL2 | CK820_G0043405 | ENSPTRP00000058328 | ENSPTRP00000064841 | ARL2-SNX15 isoform 1; Belongs to the small GTPase superfamily. Arf family. | RPGR isoform 4. | 0.463 |
ARL2 | PDE6D | ENSPTRP00000058328 | ENSPTRP00000022277 | ARL2-SNX15 isoform 1; Belongs to the small GTPase superfamily. Arf family. | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...] | 0.951 |
ARL2 | RPGR | ENSPTRP00000058328 | ENSPTRP00000079514 | ARL2-SNX15 isoform 1; Belongs to the small GTPase superfamily. Arf family. | RPGR isoform 3. | 0.463 |
ARL3 | ARL13B | ENSPTRP00000082289 | ENSPTRP00000026120 | ADP-ribosylation factor-like 3; Belongs to the small GTPase superfamily. Arf family. | ADP ribosylation factor like GTPase 13B. | 0.700 |
ARL3 | CK820_G0043405 | ENSPTRP00000082289 | ENSPTRP00000064841 | ADP-ribosylation factor-like 3; Belongs to the small GTPase superfamily. Arf family. | RPGR isoform 4. | 0.410 |
ARL3 | PDE6D | ENSPTRP00000082289 | ENSPTRP00000022277 | ADP-ribosylation factor-like 3; Belongs to the small GTPase superfamily. Arf family. | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...] | 0.922 |
ARL3 | RPGR | ENSPTRP00000082289 | ENSPTRP00000079514 | ADP-ribosylation factor-like 3; Belongs to the small GTPase superfamily. Arf family. | RPGR isoform 3. | 0.538 |
CK820_G0042963 | ARL2 | ENSPTRP00000069096 | ENSPTRP00000058328 | RHEB isoform 3. | ARL2-SNX15 isoform 1; Belongs to the small GTPase superfamily. Arf family. | 0.427 |
CK820_G0042963 | PDE6D | ENSPTRP00000069096 | ENSPTRP00000022277 | RHEB isoform 3. | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...] | 0.893 |
CK820_G0043405 | ARL2 | ENSPTRP00000064841 | ENSPTRP00000058328 | RPGR isoform 4. | ARL2-SNX15 isoform 1; Belongs to the small GTPase superfamily. Arf family. | 0.463 |
CK820_G0043405 | ARL3 | ENSPTRP00000064841 | ENSPTRP00000082289 | RPGR isoform 4. | ADP-ribosylation factor-like 3; Belongs to the small GTPase superfamily. Arf family. | 0.410 |
CK820_G0043405 | PDE6D | ENSPTRP00000064841 | ENSPTRP00000022277 | RPGR isoform 4. | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...] | 0.911 |
HPRT1 | APRT | ENSPTRP00000086770 | ENSPTRP00000014433 | Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). | Adenine phosphoribosyltransferase. | 0.970 |