STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TGM2Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase). (687 aa)    
Predicted Functional Partners:
TOR1A
Torsin.
      
 0.690
ADGRG1
Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells a [...]
   
  
 0.670
TSG101
Tumor susceptibility 101.
   
  
 0.632
RHAG
RHAG isoform 2; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
   
 
 0.612
PROC
Protein C, inactivator of coagulation factors Va and VIIIa.
     
 0.543
F13B
Coagulation factor XIII B chain.
    
 0.533
ITGB1
Integrin beta; Belongs to the integrin beta chain family.
   
 
 0.532
ARNT
Aryl hydrocarbon receptor nuclear translocator.
    
 
 0.527
IVL
Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
    
 0.514
ANXA1
Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of Fthe formyl peptide receptors (By similarity). Contribu [...]
   
 0.504
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.