node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATM | ATR | ENSPTRP00000054216 | ENSPTRP00000051017 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Ataxia telangiectasia and Rad3 related; Belongs to the PI3/PI4-kinase family. | 0.995 |
ATM | ATRIP | ENSPTRP00000054216 | ENSPTRP00000061527 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | ATR interacting protein. | 0.940 |
ATM | BRCA1 | ENSPTRP00000054216 | ENSPTRP00000070120 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.999 |
ATM | FANCA | ENSPTRP00000054216 | ENSPTRP00000014483 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | FANCA isoform 6. | 0.587 |
ATM | FANCG | ENSPTRP00000054216 | ENSPTRP00000035752 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Fanconi anemia group G protein isoform X1. | 0.628 |
ATM | FANCI | ENSPTRP00000054216 | ENSPTRP00000012702 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | FANCI isoform 2. | 0.814 |
ATM | FANCM | ENSPTRP00000054216 | ENSPTRP00000010694 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Fanconi anemia, complementation group M. | 0.663 |
ATM | RPA1 | ENSPTRP00000054216 | ENSPTRP00000014573 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.835 |
ATM | TOPBP1 | ENSPTRP00000054216 | ENSPTRP00000026557 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Topoisomerase (DNA) II binding protein 1. | 0.859 |
ATM | WRN | ENSPTRP00000054216 | ENSPTRP00000091996 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | WRN RecQ like helicase. | 0.980 |
ATR | ATM | ENSPTRP00000051017 | ENSPTRP00000054216 | Ataxia telangiectasia and Rad3 related; Belongs to the PI3/PI4-kinase family. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.995 |
ATR | ATRIP | ENSPTRP00000051017 | ENSPTRP00000061527 | Ataxia telangiectasia and Rad3 related; Belongs to the PI3/PI4-kinase family. | ATR interacting protein. | 0.999 |
ATR | BRCA1 | ENSPTRP00000051017 | ENSPTRP00000070120 | Ataxia telangiectasia and Rad3 related; Belongs to the PI3/PI4-kinase family. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.995 |
ATR | FANCA | ENSPTRP00000051017 | ENSPTRP00000014483 | Ataxia telangiectasia and Rad3 related; Belongs to the PI3/PI4-kinase family. | FANCA isoform 6. | 0.965 |
ATR | FANCG | ENSPTRP00000051017 | ENSPTRP00000035752 | Ataxia telangiectasia and Rad3 related; Belongs to the PI3/PI4-kinase family. | Fanconi anemia group G protein isoform X1. | 0.948 |
ATR | FANCI | ENSPTRP00000051017 | ENSPTRP00000012702 | Ataxia telangiectasia and Rad3 related; Belongs to the PI3/PI4-kinase family. | FANCI isoform 2. | 0.967 |
ATR | FANCM | ENSPTRP00000051017 | ENSPTRP00000010694 | Ataxia telangiectasia and Rad3 related; Belongs to the PI3/PI4-kinase family. | Fanconi anemia, complementation group M. | 0.994 |
ATR | RPA1 | ENSPTRP00000051017 | ENSPTRP00000014573 | Ataxia telangiectasia and Rad3 related; Belongs to the PI3/PI4-kinase family. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.924 |
ATR | TOPBP1 | ENSPTRP00000051017 | ENSPTRP00000026557 | Ataxia telangiectasia and Rad3 related; Belongs to the PI3/PI4-kinase family. | Topoisomerase (DNA) II binding protein 1. | 0.954 |
ATR | WRN | ENSPTRP00000051017 | ENSPTRP00000091996 | Ataxia telangiectasia and Rad3 related; Belongs to the PI3/PI4-kinase family. | WRN RecQ like helicase. | 0.987 |