STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GPR15G-protein coupled receptor 15; Probable chemokine receptor. SIV-1 coreceptor; Belongs to the G-protein coupled receptor 1 family. (360 aa)    
Predicted Functional Partners:
CLDND1
Claudin domain containing 1.
      
 0.615
CD4
T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]
      
 0.587
C10H10orf99
Chromosome 10 C10orf99 homolog.
      
 0.573
ITIH4
Inter-alpha-trypsin inhibitor heavy chain 4.
     
 0.473
GPR61
G protein-coupled receptor 61; Belongs to the G-protein coupled receptor 1 family.
     
 0.465
GSN
GSN isoform 3.
      
 0.465
ZNF80
Zinc finger protein 80; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
      
 0.465
LRRN3
Leucine rich repeat neuronal 3.
      
 0.457
GPR139
G protein-coupled receptor 139.
     
 0.456
GPR39
G protein-coupled receptor 39; Belongs to the G-protein coupled receptor 1 family.
     
 0.449
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.