STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMPRSS11ETransmembrane protease serine; Belongs to the peptidase S1 family. (423 aa)    
Predicted Functional Partners:
SERPINA5
Serpin family A member 5; Belongs to the serpin family.
    
 0.691
SPINT2
T0106202 isoform 2.
   
 0.554
SERPINE1
Serpin family E member 1; Belongs to the serpin family.
    
 0.524
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
    
 0.508
MST1R
Macrophage stimulating 1 receptor.
    
 0.507
LOC104003639
Guanine nucleotide-binding protein G(s) subunit alpha.
    
 0.477
HRC
HRC isoform 2.
    
 
 0.465
SPINT1
SPINT1 isoform 2.
   
 0.461
CTRB2
Chymotrypsinogen B2.
  
0.447
LOC736783
Chymotrypsinogen B2.
  
0.442
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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