STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
MAPK13Mitogen-activated protein kinase 13; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studie [...] (366 aa)    
Predicted Functional Partners:
MAPK12
Mitogen-activated protein kinase.
  
 
0.862
MAPKAPK2
Mitogen-activated protein kinase-activated protein kinase 2; Belongs to the protein kinase superfamily.
  
0.857
TAB1
TGF-beta activated kinase 1 (MAP3K7) binding protein 1.
   
 0.816
MAPKAPK3
Mitogen-activated protein kinase-activated protein kinase 3; Belongs to the protein kinase superfamily.
  
0.799
MEF2A
Myocyte enhancer factor 2A.
   
 0.756
MAP2K6
Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.
  
0.754
MEF2C
Myocyte enhancer factor 2C.
   
 0.751
CK820_G0053450-2
MAP2K3 isoform 2.
  
0.718
MEF2B
MADS-box transcription enhancer factor 2B.
   
 0.704
ATF2
Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.
    
 0.704
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.