DICER1 protein (Pan troglodytes) - STRING interaction network

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Score

DICER1

Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily. (1922 aa)

Predicted Functional Partners:

AGO2

0.997

PRKRA

0.996

AGO1

0.995

TARBP2

0.992

ENSPTRP00000074270

0.990

DGCR8

0.962

AGO4

0.951

AGO3

0.939

TNRC6A

0.904

XPO5

0.870

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO1	AGO2	ENSPTRP00000081341	ENSPTRP00000035263	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.996
AGO1	AGO3	ENSPTRP00000081341	ENSPTRP00000000933	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.938
AGO1	AGO4	ENSPTRP00000081341	ENSPTRP00000044180	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.885
AGO1	DGCR8	ENSPTRP00000081341	ENSPTRP00000024242	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	DiGeorge syndrome critical region gene 8.	0.832
AGO1	DICER1	ENSPTRP00000081341	ENSPTRP00000046628	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily.	0.995
AGO1	ENSPTRP00000074270	ENSPTRP00000081341	ENSPTRP00000074270	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	annotation not available	0.898
AGO1	PRKRA	ENSPTRP00000081341	ENSPTRP00000021685	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	Protein kinase, interferon-inducible double stranded RNA dependent activator.	0.855
AGO1	TARBP2	ENSPTRP00000081341	ENSPTRP00000050292	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...]	0.924
AGO1	TNRC6A	ENSPTRP00000081341	ENSPTRP00000047103	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	TNRC6A isoform 3.	0.998
AGO1	XPO5	ENSPTRP00000081341	ENSPTRP00000031109	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	XPO5 isoform 1.	0.818
AGO2	AGO1	ENSPTRP00000035263	ENSPTRP00000081341	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Eukaryotic translation initiation factor 2C, 1; Belongs to the argonaute family.	0.996
AGO2	AGO3	ENSPTRP00000035263	ENSPTRP00000000933	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.979
AGO2	AGO4	ENSPTRP00000035263	ENSPTRP00000044180	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.937
AGO2	DGCR8	ENSPTRP00000035263	ENSPTRP00000024242	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	DiGeorge syndrome critical region gene 8.	0.914
AGO2	DICER1	ENSPTRP00000035263	ENSPTRP00000046628	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily.	0.997
AGO2	ENSPTRP00000074270	ENSPTRP00000035263	ENSPTRP00000074270	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	annotation not available	0.969
AGO2	PRKRA	ENSPTRP00000035263	ENSPTRP00000021685	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein kinase, interferon-inducible double stranded RNA dependent activator.	0.879
AGO2	TARBP2	ENSPTRP00000035263	ENSPTRP00000050292	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...]	0.980
AGO2	TNRC6A	ENSPTRP00000035263	ENSPTRP00000047103	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	TNRC6A isoform 3.	0.998
AGO2	XPO5	ENSPTRP00000035263	ENSPTRP00000031109	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	XPO5 isoform 1.	0.903