node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCNA2 | CCNB1 | ENSPPYP00000016798 | ENSPPYP00000017345 | CCNA2 isoform 1; Belongs to the cyclin family. | CCNB1 isoform 1; Belongs to the cyclin family. | 0.957 |
CCNA2 | CDK1 | ENSPPYP00000016798 | ENSPPYP00000002808 | CCNA2 isoform 1; Belongs to the cyclin family. | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] | 0.999 |
CCNA2 | CDK2 | ENSPPYP00000016798 | ENSPPYP00000005283 | CCNA2 isoform 1; Belongs to the cyclin family. | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | 0.999 |
CCNA2 | CDKN1B | ENSPPYP00000016798 | ENSPPYP00000004921 | CCNA2 isoform 1; Belongs to the cyclin family. | Cyclin dependent kinase inhibitor 1B. | 0.999 |
CCNA2 | CKS1B | ENSPPYP00000016798 | ENSPPYP00000000892 | CCNA2 isoform 1; Belongs to the cyclin family. | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. | 0.983 |
CCNA2 | CKS2 | ENSPPYP00000016798 | ENSPPYP00000023475 | CCNA2 isoform 1; Belongs to the cyclin family. | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. | 0.945 |
CCNA2 | CUL1 | ENSPPYP00000016798 | ENSPPYP00000020352 | CCNA2 isoform 1; Belongs to the cyclin family. | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...] | 0.964 |
CCNA2 | RBX1 | ENSPPYP00000016798 | ENSPPYP00000013235 | CCNA2 isoform 1; Belongs to the cyclin family. | RBX1 isoform 1. | 0.935 |
CCNA2 | SKP1 | ENSPPYP00000016798 | ENSPPYP00000017649 | CCNA2 isoform 1; Belongs to the cyclin family. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.971 |
CCNA2 | SKP2 | ENSPPYP00000016798 | ENSPPYP00000017203 | CCNA2 isoform 1; Belongs to the cyclin family. | SKP2 isoform 1. | 0.994 |
CCNB1 | CCNA2 | ENSPPYP00000017345 | ENSPPYP00000016798 | CCNB1 isoform 1; Belongs to the cyclin family. | CCNA2 isoform 1; Belongs to the cyclin family. | 0.957 |
CCNB1 | CDK1 | ENSPPYP00000017345 | ENSPPYP00000002808 | CCNB1 isoform 1; Belongs to the cyclin family. | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] | 0.999 |
CCNB1 | CDK2 | ENSPPYP00000017345 | ENSPPYP00000005283 | CCNB1 isoform 1; Belongs to the cyclin family. | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. | 0.991 |
CCNB1 | CDKN1B | ENSPPYP00000017345 | ENSPPYP00000004921 | CCNB1 isoform 1; Belongs to the cyclin family. | Cyclin dependent kinase inhibitor 1B. | 0.953 |
CCNB1 | CKS1B | ENSPPYP00000017345 | ENSPPYP00000000892 | CCNB1 isoform 1; Belongs to the cyclin family. | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. | 0.974 |
CCNB1 | CKS2 | ENSPPYP00000017345 | ENSPPYP00000023475 | CCNB1 isoform 1; Belongs to the cyclin family. | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. | 0.968 |
CCNB1 | SKP1 | ENSPPYP00000017345 | ENSPPYP00000017649 | CCNB1 isoform 1; Belongs to the cyclin family. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.420 |
CCNB1 | SKP2 | ENSPPYP00000017345 | ENSPPYP00000017203 | CCNB1 isoform 1; Belongs to the cyclin family. | SKP2 isoform 1. | 0.571 |
CDK1 | CCNA2 | ENSPPYP00000002808 | ENSPPYP00000016798 | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] | CCNA2 isoform 1; Belongs to the cyclin family. | 0.999 |
CDK1 | CCNB1 | ENSPPYP00000002808 | ENSPPYP00000017345 | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] | CCNB1 isoform 1; Belongs to the cyclin family. | 0.999 |