STRINGSTRING
RORC protein (Pongo abelii) - STRING interaction network
"RORC" - Nuclear receptor ROR-gamma in Pongo abelii
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RORCNuclear receptor ROR-gamma; Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5’-AGGTCA-3’ preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25- hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectiv [...] (642 aa)    
Predicted Functional Partners:
FOXP3
Forkhead box P3 (431 aa)
       
  0.940
RORB
RAR-related orphan receptor B (516 aa)
     
0.824
RORA
RAR-related orphan receptor A (555 aa)
     
0.821
IL17A
Interleukin 17A (155 aa)
       
 
  0.805
TBX21
T-box 21 (535 aa)
           
  0.798
NRIP1
Nuclear receptor interacting protein 1 (1141 aa)
       
 
  0.774
NCOR2
Nuclear receptor corepressor 2 (2461 aa)
       
 
  0.770
ENSPPYG00000029799
Uncharacterized protein (85 aa)
       
 
  0.738
NCOA1
Nuclear receptor coactivator 1 (1293 aa)
       
 
  0.738
IL23R
Interleukin 23 receptor (629 aa)
       
 
  0.705
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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