ERG28 protein (Pongo abelii) - STRING interaction network

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[Homology]

Score

ERG28

Ergosterol biosynthetic protein 28 homolog. (140 aa)

Predicted Functional Partners:

CYP51A1

0.959

HSD17B7

0.927

SC5D

0.927

LSS

0.919

SIGMAR1

0.919

MSMO1

0.917

FDFT1

0.914

NDUFAF6

0.807

CH25H

0.777

FAXDC2

0.777

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CH25H	CYP51A1	ENSPPYP00000002851	ENSPPYP00000019976	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.	Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...]	0.941
CH25H	ERG28	ENSPPYP00000002851	ENSPPYP00000006832	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.	Ergosterol biosynthetic protein 28 homolog.	0.777
CH25H	FDFT1	ENSPPYP00000002851	ENSPPYP00000020559	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.	Squalene synthase; Critical branch point enzyme of isoprenoid biosynthesis that is thought to regulate the flux of isoprene intermediates through the sterol pathway; Belongs to the phytoene/squalene synthase family.	0.819
CH25H	HSD17B7	ENSPPYP00000002851	ENSPPYP00000000676	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.	HSD17B7 isoform 2.	0.851
CH25H	LSS	ENSPPYP00000002851	ENSPPYP00000012870	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.811
CH25H	NDUFAF6	ENSPPYP00000002851	ENSPPYP00000021041	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.	NDUFAF6 isoform 7.	0.596
CH25H	SC5D	ENSPPYP00000002851	ENSPPYP00000004558	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.	Sterol-C5-desaturase; Belongs to the sterol desaturase family.	0.934
CH25H	SIGMAR1	ENSPPYP00000002851	ENSPPYP00000021422	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.	Sigma non-opioid intracellular receptor 1.	0.822
CYP51A1	CH25H	ENSPPYP00000019976	ENSPPYP00000002851	Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...]	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.	0.941
CYP51A1	ERG28	ENSPPYP00000019976	ENSPPYP00000006832	Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...]	Ergosterol biosynthetic protein 28 homolog.	0.959
CYP51A1	FAXDC2	ENSPPYP00000019976	ENSPPYP00000017878	Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...]	Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family.	0.939
CYP51A1	FDFT1	ENSPPYP00000019976	ENSPPYP00000020559	Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...]	Squalene synthase; Critical branch point enzyme of isoprenoid biosynthesis that is thought to regulate the flux of isoprene intermediates through the sterol pathway; Belongs to the phytoene/squalene synthase family.	0.975
CYP51A1	HSD17B7	ENSPPYP00000019976	ENSPPYP00000000676	Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...]	HSD17B7 isoform 2.	0.968
CYP51A1	LSS	ENSPPYP00000019976	ENSPPYP00000012870	Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...]	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.985
CYP51A1	MSMO1	ENSPPYP00000019976	ENSPPYP00000016960	Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...]	Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family.	0.964
CYP51A1	SC5D	ENSPPYP00000019976	ENSPPYP00000004558	Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...]	Sterol-C5-desaturase; Belongs to the sterol desaturase family.	0.945
CYP51A1	SIGMAR1	ENSPPYP00000019976	ENSPPYP00000021422	Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...]	Sigma non-opioid intracellular receptor 1.	0.927
ERG28	CH25H	ENSPPYP00000006832	ENSPPYP00000002851	Ergosterol biosynthetic protein 28 homolog.	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.	0.777
ERG28	CYP51A1	ENSPPYP00000006832	ENSPPYP00000019976	Ergosterol biosynthetic protein 28 homolog.	Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...]	0.959
ERG28	FAXDC2	ENSPPYP00000006832	ENSPPYP00000017878	Ergosterol biosynthetic protein 28 homolog.	Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family.	0.777