node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CENPX | FAAP100 | ENSPPYP00000009834 | ENSPPYP00000009806 | Centromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked rep [...] | FAAP100 isoform 1. | 0.988 |
CENPX | FAAP24 | ENSPPYP00000009834 | ENSPPYP00000024336 | Centromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked rep [...] | FAAP24 isoform 3. | 0.990 |
CENPX | FANCA | ENSPPYP00000009834 | ENSPPYP00000008650 | Centromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked rep [...] | FANCA isoform 6. | 0.969 |
CENPX | FANCB | ENSPPYP00000009834 | ENSPPYP00000022528 | Centromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked rep [...] | FANCB isoform 1. | 0.917 |
CENPX | FANCC | ENSPPYP00000009834 | ENSPPYP00000021749 | Centromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked rep [...] | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. | 0.985 |
CENPX | FANCD2 | ENSPPYP00000009834 | ENSPPYP00000015279 | Centromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked rep [...] | FANCD2 isoform 1. | 0.956 |
CENPX | FANCF | ENSPPYP00000009834 | ENSPPYP00000003923 | Centromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked rep [...] | FA complementation group F. | 0.988 |
CENPX | FANCG | ENSPPYP00000009834 | ENSPPYP00000021407 | Centromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked rep [...] | FA complementation group G. | 0.986 |
CENPX | FANCL | ENSPPYP00000009834 | ENSPPYP00000013826 | Centromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked rep [...] | FA complementation group L. | 0.988 |
CENPX | FANCM | ENSPPYP00000009834 | ENSPPYP00000006571 | Centromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked rep [...] | FANCM isoform 2. | 0.960 |
FAAP100 | CENPX | ENSPPYP00000009806 | ENSPPYP00000009834 | FAAP100 isoform 1. | Centromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked rep [...] | 0.988 |
FAAP100 | FAAP24 | ENSPPYP00000009806 | ENSPPYP00000024336 | FAAP100 isoform 1. | FAAP24 isoform 3. | 0.999 |
FAAP100 | FANCA | ENSPPYP00000009806 | ENSPPYP00000008650 | FAAP100 isoform 1. | FANCA isoform 6. | 0.976 |
FAAP100 | FANCB | ENSPPYP00000009806 | ENSPPYP00000022528 | FAAP100 isoform 1. | FANCB isoform 1. | 0.999 |
FAAP100 | FANCC | ENSPPYP00000009806 | ENSPPYP00000021749 | FAAP100 isoform 1. | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. | 0.999 |
FAAP100 | FANCD2 | ENSPPYP00000009806 | ENSPPYP00000015279 | FAAP100 isoform 1. | FANCD2 isoform 1. | 0.994 |
FAAP100 | FANCF | ENSPPYP00000009806 | ENSPPYP00000003923 | FAAP100 isoform 1. | FA complementation group F. | 0.999 |
FAAP100 | FANCG | ENSPPYP00000009806 | ENSPPYP00000021407 | FAAP100 isoform 1. | FA complementation group G. | 0.999 |
FAAP100 | FANCL | ENSPPYP00000009806 | ENSPPYP00000013826 | FAAP100 isoform 1. | FA complementation group L. | 0.999 |
FAAP100 | FANCM | ENSPPYP00000009806 | ENSPPYP00000006571 | FAAP100 isoform 1. | FANCM isoform 2. | 0.999 |