node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CR201_G0037179 | DDX23 | ENSPPYP00000010397 | ENSPPYP00000005101 | Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. | 0.995 |
CR201_G0037179 | EFTUD2 | ENSPPYP00000010397 | ENSPPYP00000009352 | Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. | 116 kDa U5 small nuclear ribonucleoprotein component; Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (By similarity). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (By similarity). | 0.995 |
CR201_G0037179 | PRPF4 | ENSPPYP00000010397 | ENSPPYP00000021870 | Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. | pre-mRNA processing factor 4. | 0.943 |
CR201_G0037179 | PRPF6 | ENSPPYP00000010397 | ENSPPYP00000012574 | Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. | Pre-mRNA-processing factor 6; Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. | 0.999 |
CR201_G0037179 | PRPF8 | ENSPPYP00000010397 | ENSPPYP00000008763 | Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. | Pre-mRNA processing factor 8. | 0.995 |
CR201_G0037179 | SF3B3 | ENSPPYP00000010397 | ENSPPYP00000008511 | Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. | Splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mR [...] | 0.851 |
CR201_G0037179 | SNRNP200 | ENSPPYP00000010397 | ENSPPYP00000013456 | Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. | Small nuclear ribonucleoprotein U5 subunit 200. | 0.993 |
CR201_G0037179 | SNRNP40 | ENSPPYP00000010397 | ENSPPYP00000001868 | Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. | U5 small nuclear ribonucleoprotein 40 kDa protein; Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome. | 0.993 |
CR201_G0037179 | SNRPD1 | ENSPPYP00000010397 | ENSPPYP00000023503 | Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. | Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. | 0.937 |
CR201_G0037179 | SNRPD3 | ENSPPYP00000010397 | ENSPPYP00000012995 | Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. | Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing. | 0.977 |
DDX23 | CR201_G0037179 | ENSPPYP00000005101 | ENSPPYP00000010397 | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. | Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. | 0.995 |
DDX23 | EFTUD2 | ENSPPYP00000005101 | ENSPPYP00000009352 | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. | 116 kDa U5 small nuclear ribonucleoprotein component; Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (By similarity). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (By similarity). | 0.996 |
DDX23 | PRPF4 | ENSPPYP00000005101 | ENSPPYP00000021870 | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. | pre-mRNA processing factor 4. | 0.971 |
DDX23 | PRPF6 | ENSPPYP00000005101 | ENSPPYP00000012574 | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. | Pre-mRNA-processing factor 6; Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. | 0.997 |
DDX23 | PRPF8 | ENSPPYP00000005101 | ENSPPYP00000008763 | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. | Pre-mRNA processing factor 8. | 0.996 |
DDX23 | SF3B3 | ENSPPYP00000005101 | ENSPPYP00000008511 | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. | Splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mR [...] | 0.872 |
DDX23 | SNRNP200 | ENSPPYP00000005101 | ENSPPYP00000013456 | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. | Small nuclear ribonucleoprotein U5 subunit 200. | 0.997 |
DDX23 | SNRNP40 | ENSPPYP00000005101 | ENSPPYP00000001868 | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. | U5 small nuclear ribonucleoprotein 40 kDa protein; Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome. | 0.995 |
DDX23 | SNRPD1 | ENSPPYP00000005101 | ENSPPYP00000023503 | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. | Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. | 0.976 |
DDX23 | SNRPD3 | ENSPPYP00000005101 | ENSPPYP00000012995 | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. | Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing. | 0.976 |