node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP6AP1 | ATP6V0A1 | ENSPPYP00000023369 | ENSPPYP00000009433 | ATPase H+ transporting accessory protein 1. | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). | 0.994 |
ATP6AP1 | ATP6V0A2 | ENSPPYP00000023369 | ENSPPYP00000005803 | ATPase H+ transporting accessory protein 1. | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. | 0.989 |
ATP6AP1 | ATP6V0B | ENSPPYP00000023369 | ENSPPYP00000001666 | ATPase H+ transporting accessory protein 1. | ATP6V0B isoform 3; Belongs to the V-ATPase proteolipid subunit family. | 0.998 |
ATP6AP1 | ATP6V0C | ENSPPYP00000023369 | ENSPPYP00000007925 | ATPase H+ transporting accessory protein 1. | V-type H+-transporting ATPase 16kDa proteolipid subunit. | 0.998 |
ATP6AP1 | ATP6V0D1 | ENSPPYP00000023369 | ENSPPYP00000008426 | ATPase H+ transporting accessory protein 1. | V-type proton ATPase subunit d 1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the acti [...] | 0.997 |
ATP6AP1 | ATP6V0D2 | ENSPPYP00000023369 | ENSPPYP00000020999 | ATPase H+ transporting accessory protein 1. | V-type proton ATPase subunit d 2; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity); Belongs to the V-ATPase V0D/AC39 subunit family. | 0.993 |
ATP6AP1 | ATP6V1A | ENSPPYP00000023369 | ENSPPYP00000015134 | ATPase H+ transporting accessory protein 1. | V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity. Belongs to the ATPase alpha/beta chains family. | 0.976 |
ATP6AP1 | ATP6V1D | ENSPPYP00000023369 | ENSPPYP00000006728 | ATPase H+ transporting accessory protein 1. | V-type proton ATPase subunit D; Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). | 0.962 |
ATP6AP1 | ATP6V1H | ENSPPYP00000023369 | ENSPPYP00000020844 | ATPase H+ transporting accessory protein 1. | V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. | 0.997 |
ATP6AP1 | TCIRG1 | ENSPPYP00000023369 | ENSPPYP00000003450 | ATPase H+ transporting accessory protein 1. | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. | 0.979 |
ATP6V0A1 | ATP6AP1 | ENSPPYP00000009433 | ENSPPYP00000023369 | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). | ATPase H+ transporting accessory protein 1. | 0.994 |
ATP6V0A1 | ATP6V0A2 | ENSPPYP00000009433 | ENSPPYP00000005803 | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. | 0.994 |
ATP6V0A1 | ATP6V0B | ENSPPYP00000009433 | ENSPPYP00000001666 | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). | ATP6V0B isoform 3; Belongs to the V-ATPase proteolipid subunit family. | 0.998 |
ATP6V0A1 | ATP6V0C | ENSPPYP00000009433 | ENSPPYP00000007925 | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). | V-type H+-transporting ATPase 16kDa proteolipid subunit. | 0.998 |
ATP6V0A1 | ATP6V0D1 | ENSPPYP00000009433 | ENSPPYP00000008426 | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). | V-type proton ATPase subunit d 1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the acti [...] | 0.997 |
ATP6V0A1 | ATP6V0D2 | ENSPPYP00000009433 | ENSPPYP00000020999 | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). | V-type proton ATPase subunit d 2; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity); Belongs to the V-ATPase V0D/AC39 subunit family. | 0.996 |
ATP6V0A1 | ATP6V1A | ENSPPYP00000009433 | ENSPPYP00000015134 | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). | V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity. Belongs to the ATPase alpha/beta chains family. | 0.995 |
ATP6V0A1 | ATP6V1D | ENSPPYP00000009433 | ENSPPYP00000006728 | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). | V-type proton ATPase subunit D; Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). | 0.993 |
ATP6V0A1 | ATP6V1H | ENSPPYP00000009433 | ENSPPYP00000020844 | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). | V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. | 0.996 |
ATP6V0A1 | TCIRG1 | ENSPPYP00000009433 | ENSPPYP00000003450 | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. | 0.992 |