STRINGSTRING
TP53RK protein (Pongo abelii) - STRING interaction network
"TP53RK" - TP53 regulating kinase in Pongo abelii
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP53RKTP53 regulating kinase (253 aa)    
Predicted Functional Partners:
TPRKB
TP53RK binding protein (120 aa)
       
  0.991
OSGEPL1
O-sialoglycoprotein endopeptidase-like 1 (414 aa)
 
  0.977
GLRX3
Glutaredoxin 3 (335 aa)
     
 
  0.796
ENSPPYG00000016185
Uncharacterized protein (312 aa)
     
 
  0.631
GLRX5
Glutaredoxin 5 (157 aa)
     
 
  0.631
C14orf142
Chromosome 14 open reading frame 142 (100 aa)
       
 
  0.603
NUP43
Nucleoporin 43kDa (445 aa)
       
      0.594
SLC2A13
Solute carrier family 2 (facilitated glucose transporter), member 13 (647 aa)
     
   
  0.562
TP53
Tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (393 aa)
       
  0.531
SARS2
seryl-tRNA synthetase, mitochondrial (518 aa)
     
 
  0.520
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Ponginae, Pongo, Pongo abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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