STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PMS1PMS1 isoform 2. (930 aa)    
Predicted Functional Partners:
MSH2
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
  
 0.995
MLH1
MLH1 isoform 1.
    
 0.990
MSH6
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
  
 0.983
MSH3
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
 
 0.972
FAN1
Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.
   
 
 0.903
EXO1
EXO1 isoform 1.
   
 0.897
MLH3
MLH3 isoform 1.
    
 0.882
MSH5
MSH5 isoform 1.
  
 0.856
POLD1
DNA polymerase delta catalytic subunit.
   
 0.785
CR201_G0053891
PMS2 isoform 6.
  
0.781
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.