node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CTSA | GALNS | ENSPPYP00000012380 | ENSPPYP00000008628 | Carboxypeptidase; Belongs to the peptidase S10 family. | GALNS isoform 3. | 0.595 |
CTSA | GLB1 | ENSPPYP00000012380 | ENSPPYP00000015702 | Carboxypeptidase; Belongs to the peptidase S10 family. | Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family. | 0.994 |
GALM | GLA | ENSPPYP00000013940 | ENSPPYP00000023601 | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity). | Alpha-galactosidase. | 0.914 |
GALM | GLB1 | ENSPPYP00000013940 | ENSPPYP00000015702 | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity). | Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family. | 0.924 |
GALM | HEXA | ENSPPYP00000013940 | ENSPPYP00000007503 | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity). | Beta-hexosaminidase subunit alpha; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. | 0.433 |
GALM | LCT | ENSPPYP00000013940 | ENSPPYP00000014306 | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity). | LCT isoform 1. | 0.920 |
GALNS | CTSA | ENSPPYP00000008628 | ENSPPYP00000012380 | GALNS isoform 3. | Carboxypeptidase; Belongs to the peptidase S10 family. | 0.595 |
GALNS | GLB1 | ENSPPYP00000008628 | ENSPPYP00000015702 | GALNS isoform 3. | Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family. | 0.982 |
GALNS | GNS | ENSPPYP00000008628 | ENSPPYP00000005389 | GALNS isoform 3. | N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. | 0.448 |
GBA | GLA | ENSPPYP00000000872 | ENSPPYP00000023601 | Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] | Alpha-galactosidase. | 0.634 |
GBA | GLB1 | ENSPPYP00000000872 | ENSPPYP00000015702 | Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] | Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family. | 0.956 |
GLA | GALM | ENSPPYP00000023601 | ENSPPYP00000013940 | Alpha-galactosidase. | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity). | 0.914 |
GLA | GBA | ENSPPYP00000023601 | ENSPPYP00000000872 | Alpha-galactosidase. | Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] | 0.634 |
GLA | GLB1 | ENSPPYP00000023601 | ENSPPYP00000015702 | Alpha-galactosidase. | Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family. | 0.974 |
GLA | HEXA | ENSPPYP00000023601 | ENSPPYP00000007503 | Alpha-galactosidase. | Beta-hexosaminidase subunit alpha; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. | 0.940 |
GLA | HEXB | ENSPPYP00000023601 | ENSPPYP00000024213 | Alpha-galactosidase. | Beta-hexosaminidase. | 0.928 |
GLA | LCT | ENSPPYP00000023601 | ENSPPYP00000014306 | Alpha-galactosidase. | LCT isoform 1. | 0.912 |
GLB1 | CTSA | ENSPPYP00000015702 | ENSPPYP00000012380 | Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family. | Carboxypeptidase; Belongs to the peptidase S10 family. | 0.994 |
GLB1 | GALM | ENSPPYP00000015702 | ENSPPYP00000013940 | Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family. | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity). | 0.924 |
GLB1 | GALNS | ENSPPYP00000015702 | ENSPPYP00000008628 | Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family. | GALNS isoform 3. | 0.982 |