node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AANAT | PPM1L | ENSPPYP00000009726 | ENSPPYP00000015943 | AANAT isoform 2. | Protein phosphatase, Mg2+/Mn2+ dependent 1L. | 0.567 |
BCKDHA | BCKDHB | ENSPPYP00000011210 | ENSPPYP00000018803 | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | BCKDHB isoform 1. | 0.999 |
BCKDHA | DBT | ENSPPYP00000011210 | ENSPPYP00000001294 | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | 0.984 |
BCKDHA | PPM1L | ENSPPYP00000011210 | ENSPPYP00000015943 | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | Protein phosphatase, Mg2+/Mn2+ dependent 1L. | 0.618 |
BCKDHB | BCKDHA | ENSPPYP00000018803 | ENSPPYP00000011210 | BCKDHB isoform 1. | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | 0.999 |
BCKDHB | DBT | ENSPPYP00000018803 | ENSPPYP00000001294 | BCKDHB isoform 1. | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | 0.983 |
BCKDHB | PPM1L | ENSPPYP00000018803 | ENSPPYP00000015943 | BCKDHB isoform 1. | Protein phosphatase, Mg2+/Mn2+ dependent 1L. | 0.681 |
DBT | BCKDHA | ENSPPYP00000001294 | ENSPPYP00000011210 | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | 0.984 |
DBT | BCKDHB | ENSPPYP00000001294 | ENSPPYP00000018803 | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | BCKDHB isoform 1. | 0.983 |
DBT | PPM1L | ENSPPYP00000001294 | ENSPPYP00000015943 | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | Protein phosphatase, Mg2+/Mn2+ dependent 1L. | 0.601 |
MAP2K3 | MAP3K7 | ENSPPYP00000009080 | ENSPPYP00000018861 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | 0.970 |
MAP2K3 | PPM1L | ENSPPYP00000009080 | ENSPPYP00000015943 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. | Protein phosphatase, Mg2+/Mn2+ dependent 1L. | 0.514 |
MAP3K7 | MAP2K3 | ENSPPYP00000018861 | ENSPPYP00000009080 | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. | 0.970 |
MAP3K7 | PPM1L | ENSPPYP00000018861 | ENSPPYP00000015943 | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | Protein phosphatase, Mg2+/Mn2+ dependent 1L. | 0.544 |
MAP3K7 | PPP5C | ENSPPYP00000018861 | ENSPPYP00000011348 | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | Serine/threonine-protein phosphatase. | 0.462 |
MTFMT | PPM1L | ENSPPYP00000007439 | ENSPPYP00000015943 | Mitochondrial methionyl-tRNA formyltransferase. | Protein phosphatase, Mg2+/Mn2+ dependent 1L. | 0.515 |
PPM1L | AANAT | ENSPPYP00000015943 | ENSPPYP00000009726 | Protein phosphatase, Mg2+/Mn2+ dependent 1L. | AANAT isoform 2. | 0.567 |
PPM1L | BCKDHA | ENSPPYP00000015943 | ENSPPYP00000011210 | Protein phosphatase, Mg2+/Mn2+ dependent 1L. | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | 0.618 |
PPM1L | BCKDHB | ENSPPYP00000015943 | ENSPPYP00000018803 | Protein phosphatase, Mg2+/Mn2+ dependent 1L. | BCKDHB isoform 1. | 0.681 |
PPM1L | DBT | ENSPPYP00000015943 | ENSPPYP00000001294 | Protein phosphatase, Mg2+/Mn2+ dependent 1L. | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | 0.601 |