node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAA1 | ACAT1 | ENSPPYP00000015674 | ENSPPYP00000004400 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 0.925 |
ACAA1 | ACAT2 | ENSPPYP00000015674 | ENSPPYP00000019199 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | 0.919 |
ACAA1 | AUH | ENSPPYP00000015674 | ENSPPYP00000021702 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | AUH isoform 1; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.753 |
ACAA1 | EHHADH | ENSPPYP00000015674 | ENSPPYP00000016064 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. | 0.993 |
ACAA1 | HADH | ENSPPYP00000015674 | ENSPPYP00000016738 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxyacyl-CoA dehydrogenase. | 0.991 |
ACAA1 | HADHB | ENSPPYP00000015674 | ENSPPYP00000014050 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | HADHB isoform 3; Belongs to the thiolase-like superfamily. Thiolase family. | 0.934 |
ACAA1 | HMGCS1 | ENSPPYP00000015674 | ENSPPYP00000017251 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.983 |
ACAT1 | ACAA1 | ENSPPYP00000004400 | ENSPPYP00000015674 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 0.925 |
ACAT1 | ACAT2 | ENSPPYP00000004400 | ENSPPYP00000019199 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | 0.917 |
ACAT1 | AUH | ENSPPYP00000004400 | ENSPPYP00000021702 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | AUH isoform 1; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.692 |
ACAT1 | CYP51A1 | ENSPPYP00000004400 | ENSPPYP00000019976 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | 0.480 |
ACAT1 | EHHADH | ENSPPYP00000004400 | ENSPPYP00000016064 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. | 0.972 |
ACAT1 | FDPS | ENSPPYP00000004400 | ENSPPYP00000000868 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | FDPS isoform 12; Belongs to the FPP/GGPP synthase family. | 0.508 |
ACAT1 | HADH | ENSPPYP00000004400 | ENSPPYP00000016738 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxyacyl-CoA dehydrogenase. | 0.985 |
ACAT1 | HADHB | ENSPPYP00000004400 | ENSPPYP00000014050 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | HADHB isoform 3; Belongs to the thiolase-like superfamily. Thiolase family. | 0.928 |
ACAT1 | HMGCR | ENSPPYP00000004400 | ENSPPYP00000017394 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins; Belongs to the HMG-CoA reductase family. | 0.569 |
ACAT1 | HMGCS1 | ENSPPYP00000004400 | ENSPPYP00000017251 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.993 |
ACAT2 | ACAA1 | ENSPPYP00000019199 | ENSPPYP00000015674 | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 0.919 |
ACAT2 | ACAT1 | ENSPPYP00000019199 | ENSPPYP00000004400 | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 0.917 |
ACAT2 | AUH | ENSPPYP00000019199 | ENSPPYP00000021702 | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | AUH isoform 1; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.692 |