node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BUB1 | CDC20 | ENSPPYP00000013551 | ENSPPYP00000001678 | BUB1 mitotic checkpoint serine/threonine kinase. | Cell division cycle 20. | 0.999 |
BUB1 | ESPL1 | ENSPPYP00000013551 | ENSPPYP00000005218 | BUB1 mitotic checkpoint serine/threonine kinase. | ESPL1 isoform 1. | 0.959 |
BUB1 | FZR1 | ENSPPYP00000013551 | ENSPPYP00000010515 | BUB1 mitotic checkpoint serine/threonine kinase. | FZR1 isoform 4. | 0.816 |
BUB1 | KIF23 | ENSPPYP00000013551 | ENSPPYP00000007483 | BUB1 mitotic checkpoint serine/threonine kinase. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.894 |
BUB1 | PLK1 | ENSPPYP00000013551 | ENSPPYP00000008136 | BUB1 mitotic checkpoint serine/threonine kinase. | Serine/threonine-protein kinase PLK. | 0.987 |
BUB1 | PLK2 | ENSPPYP00000013551 | ENSPPYP00000017300 | BUB1 mitotic checkpoint serine/threonine kinase. | Serine/threonine-protein kinase PLK2; Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 an [...] | 0.772 |
BUB1 | PLK4 | ENSPPYP00000013551 | ENSPPYP00000016820 | BUB1 mitotic checkpoint serine/threonine kinase. | Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit [...] | 0.917 |
BUB1 | TP53 | ENSPPYP00000013551 | ENSPPYP00000008923 | BUB1 mitotic checkpoint serine/threonine kinase. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.419 |
CDC20 | BUB1 | ENSPPYP00000001678 | ENSPPYP00000013551 | Cell division cycle 20. | BUB1 mitotic checkpoint serine/threonine kinase. | 0.999 |
CDC20 | ESPL1 | ENSPPYP00000001678 | ENSPPYP00000005218 | Cell division cycle 20. | ESPL1 isoform 1. | 0.937 |
CDC20 | FZR1 | ENSPPYP00000001678 | ENSPPYP00000010515 | Cell division cycle 20. | FZR1 isoform 4. | 0.875 |
CDC20 | KIF23 | ENSPPYP00000001678 | ENSPPYP00000007483 | Cell division cycle 20. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.648 |
CDC20 | PLK1 | ENSPPYP00000001678 | ENSPPYP00000008136 | Cell division cycle 20. | Serine/threonine-protein kinase PLK. | 0.999 |
CDC20 | PLK2 | ENSPPYP00000001678 | ENSPPYP00000017300 | Cell division cycle 20. | Serine/threonine-protein kinase PLK2; Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 an [...] | 0.763 |
CDC20 | PLK4 | ENSPPYP00000001678 | ENSPPYP00000016820 | Cell division cycle 20. | Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit [...] | 0.718 |
CDC20 | TP53 | ENSPPYP00000001678 | ENSPPYP00000008923 | Cell division cycle 20. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.489 |
CENPJ | ITSN2 | ENSPPYP00000005941 | ENSPPYP00000014069 | CENPJ isoform 2. | ITSN2 isoform 3. | 0.990 |
CENPJ | PLK1 | ENSPPYP00000005941 | ENSPPYP00000008136 | CENPJ isoform 2. | Serine/threonine-protein kinase PLK. | 0.950 |
CENPJ | PLK2 | ENSPPYP00000005941 | ENSPPYP00000017300 | CENPJ isoform 2. | Serine/threonine-protein kinase PLK2; Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 an [...] | 0.803 |
CENPJ | PLK4 | ENSPPYP00000005941 | ENSPPYP00000016820 | CENPJ isoform 2. | Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit [...] | 0.933 |