node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DDX23 | PRPF31 | ENSPPYP00000005101 | ENSPPYP00000024738 | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. | Pre-mRNA processing factor 31. | 0.965 |
DDX23 | PRPF4B | ENSPPYP00000005101 | ENSPPYP00000018106 | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. | Serine/threonine-protein kinase PRP4 homolog; Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. | 0.919 |
DDX23 | PRPF6 | ENSPPYP00000005101 | ENSPPYP00000012574 | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. | Pre-mRNA-processing factor 6; Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. | 0.997 |
DDX23 | RBM39 | ENSPPYP00000005101 | ENSPPYP00000012240 | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. | RNA-binding protein 39; Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process. | 0.459 |
DDX23 | SF3B1 | ENSPPYP00000005101 | ENSPPYP00000014574 | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. | SF3B1 isoform 1. | 0.951 |
DDX23 | SRRM1 | ENSPPYP00000005101 | ENSPPYP00000001983 | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. | Serine/arginine repetitive matrix protein 1; Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with lo [...] | 0.407 |
DDX23 | SRRT | ENSPPYP00000005101 | ENSPPYP00000019542 | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. | Serrate RNA effector molecule homolog; Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. [...] | 0.458 |
PRPF31 | DDX23 | ENSPPYP00000024738 | ENSPPYP00000005101 | Pre-mRNA processing factor 31. | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. | 0.965 |
PRPF31 | PRPF4B | ENSPPYP00000024738 | ENSPPYP00000018106 | Pre-mRNA processing factor 31. | Serine/threonine-protein kinase PRP4 homolog; Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. | 0.922 |
PRPF31 | PRPF6 | ENSPPYP00000024738 | ENSPPYP00000012574 | Pre-mRNA processing factor 31. | Pre-mRNA-processing factor 6; Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. | 0.999 |
PRPF31 | SF3B1 | ENSPPYP00000024738 | ENSPPYP00000014574 | Pre-mRNA processing factor 31. | SF3B1 isoform 1. | 0.942 |
PRPF31 | SMU1 | ENSPPYP00000024738 | ENSPPYP00000021445 | Pre-mRNA processing factor 31. | WD_REPEATS_REGION domain-containing protein. | 0.883 |
PRPF31 | SRRM2 | ENSPPYP00000024738 | ENSPPYP00000007933 | Pre-mRNA processing factor 31. | SRRM2 isoform 1. | 0.404 |
PRPF4B | DDX23 | ENSPPYP00000018106 | ENSPPYP00000005101 | Serine/threonine-protein kinase PRP4 homolog; Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. | 0.919 |
PRPF4B | PRPF31 | ENSPPYP00000018106 | ENSPPYP00000024738 | Serine/threonine-protein kinase PRP4 homolog; Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. | Pre-mRNA processing factor 31. | 0.922 |
PRPF4B | PRPF6 | ENSPPYP00000018106 | ENSPPYP00000012574 | Serine/threonine-protein kinase PRP4 homolog; Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. | Pre-mRNA-processing factor 6; Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. | 0.921 |
PRPF4B | RBM39 | ENSPPYP00000018106 | ENSPPYP00000012240 | Serine/threonine-protein kinase PRP4 homolog; Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. | RNA-binding protein 39; Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process. | 0.920 |
PRPF4B | SF3B1 | ENSPPYP00000018106 | ENSPPYP00000014574 | Serine/threonine-protein kinase PRP4 homolog; Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. | SF3B1 isoform 1. | 0.941 |
PRPF4B | SMU1 | ENSPPYP00000018106 | ENSPPYP00000021445 | Serine/threonine-protein kinase PRP4 homolog; Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. | WD_REPEATS_REGION domain-containing protein. | 0.928 |
PRPF4B | SRRM1 | ENSPPYP00000018106 | ENSPPYP00000001983 | Serine/threonine-protein kinase PRP4 homolog; Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. | Serine/arginine repetitive matrix protein 1; Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with lo [...] | 0.918 |