node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGT | AVP | ENSPPYP00000000122 | ENSPPYP00000012093 | AGT isoform 1; Belongs to the serpin family. | AVP isoform 1; Belongs to the vasopressin/oxytocin family. | 0.701 |
AGT | F2 | ENSPPYP00000000122 | ENSPPYP00000003807 | AGT isoform 1; Belongs to the serpin family. | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | 0.700 |
AGT | GNA12 | ENSPPYP00000000122 | ENSPPYP00000019410 | AGT isoform 1; Belongs to the serpin family. | GNA12 isoform 1. | 0.472 |
AGT | GRM3 | ENSPPYP00000000122 | ENSPPYP00000020006 | AGT isoform 1; Belongs to the serpin family. | Metabotropic glutamate receptor 3; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity (By similarity). | 0.927 |
AVP | AGT | ENSPPYP00000012093 | ENSPPYP00000000122 | AVP isoform 1; Belongs to the vasopressin/oxytocin family. | AGT isoform 1; Belongs to the serpin family. | 0.701 |
AVP | F2 | ENSPPYP00000012093 | ENSPPYP00000003807 | AVP isoform 1; Belongs to the vasopressin/oxytocin family. | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | 0.405 |
AVP | GRM3 | ENSPPYP00000012093 | ENSPPYP00000020006 | AVP isoform 1; Belongs to the vasopressin/oxytocin family. | Metabotropic glutamate receptor 3; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity (By similarity). | 0.910 |
F2 | AGT | ENSPPYP00000003807 | ENSPPYP00000000122 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | AGT isoform 1; Belongs to the serpin family. | 0.700 |
F2 | AVP | ENSPPYP00000003807 | ENSPPYP00000012093 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | AVP isoform 1; Belongs to the vasopressin/oxytocin family. | 0.405 |
F2 | GRM3 | ENSPPYP00000003807 | ENSPPYP00000020006 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | Metabotropic glutamate receptor 3; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity (By similarity). | 0.907 |
GNA12 | AGT | ENSPPYP00000019410 | ENSPPYP00000000122 | GNA12 isoform 1. | AGT isoform 1; Belongs to the serpin family. | 0.472 |
GNA12 | GNA13 | ENSPPYP00000019410 | ENSPPYP00000009607 | GNA12 isoform 1. | G protein subunit alpha 13. | 0.988 |
GNA12 | GNAS | ENSPPYP00000019410 | ENSPPYP00000012485 | GNA12 isoform 1. | GNAS isoform 2. | 0.695 |
GNA12 | GRM3 | ENSPPYP00000019410 | ENSPPYP00000020006 | GNA12 isoform 1. | Metabotropic glutamate receptor 3; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity (By similarity). | 0.919 |
GNA13 | GNA12 | ENSPPYP00000009607 | ENSPPYP00000019410 | G protein subunit alpha 13. | GNA12 isoform 1. | 0.988 |
GNA13 | GNAS | ENSPPYP00000009607 | ENSPPYP00000012485 | G protein subunit alpha 13. | GNAS isoform 2. | 0.463 |
GNA13 | GRM3 | ENSPPYP00000009607 | ENSPPYP00000020006 | G protein subunit alpha 13. | Metabotropic glutamate receptor 3; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity (By similarity). | 0.919 |
GNAI1 | GNAI2 | ENSPPYP00000020020 | ENSPPYP00000015499 | Guanine nucleotide-binding protein G(i) subunit alpha-1. | GNAI2 isoform 1. | 0.955 |
GNAI1 | GNAI3 | ENSPPYP00000020020 | ENSPPYP00000001241 | Guanine nucleotide-binding protein G(i) subunit alpha-1. | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] | 0.988 |
GNAI1 | GNAS | ENSPPYP00000020020 | ENSPPYP00000012485 | Guanine nucleotide-binding protein G(i) subunit alpha-1. | GNAS isoform 2. | 0.487 |