Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AK2 | DUSP26 | ENSPPYP00000001820 | ENSPPYP00000020739 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.502 |
| DUSP26 | AK2 | ENSPPYP00000020739 | ENSPPYP00000001820 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. | 0.502 |
| DUSP26 | HSF4 | ENSPPYP00000020739 | ENSPPYP00000008407 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | HSF4 isoform 10. | 0.412 |
| DUSP26 | MOB1A | ENSPPYP00000020739 | ENSPPYP00000013698 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] | 0.407 |
| DUSP26 | MTHFSD | ENSPPYP00000020739 | ENSPPYP00000008601 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | MTHFSD isoform 6. | 0.445 |
| DUSP26 | NPAS4 | ENSPPYP00000020739 | ENSPPYP00000003503 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Neuronal PAS domain protein 4. | 0.402 |
| DUSP26 | PSMD1 | ENSPPYP00000020739 | ENSPPYP00000014825 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. | 0.424 |
| DUSP26 | UTP15 | ENSPPYP00000020739 | ENSPPYP00000017381 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | U3 small nucleolar RNA-associated protein 15 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. | 0.418 |
| DUSP26 | VRK3 | ENSPPYP00000020739 | ENSPPYP00000011500 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | VRK3 isoform 3. | 0.488 |
| HSF4 | DUSP26 | ENSPPYP00000008407 | ENSPPYP00000020739 | HSF4 isoform 10. | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.412 |
| MOB1A | DUSP26 | ENSPPYP00000013698 | ENSPPYP00000020739 | MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.407 |
| MTHFSD | DUSP26 | ENSPPYP00000008601 | ENSPPYP00000020739 | MTHFSD isoform 6. | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.445 |
| MTHFSD | NPAS4 | ENSPPYP00000008601 | ENSPPYP00000003503 | MTHFSD isoform 6. | Neuronal PAS domain protein 4. | 0.683 |
| MTHFSD | PSMD1 | ENSPPYP00000008601 | ENSPPYP00000014825 | MTHFSD isoform 6. | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. | 0.689 |
| MTHFSD | UTP15 | ENSPPYP00000008601 | ENSPPYP00000017381 | MTHFSD isoform 6. | U3 small nucleolar RNA-associated protein 15 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. | 0.755 |
| NPAS4 | DUSP26 | ENSPPYP00000003503 | ENSPPYP00000020739 | Neuronal PAS domain protein 4. | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.402 |
| NPAS4 | MTHFSD | ENSPPYP00000003503 | ENSPPYP00000008601 | Neuronal PAS domain protein 4. | MTHFSD isoform 6. | 0.683 |
| NPAS4 | PSMD1 | ENSPPYP00000003503 | ENSPPYP00000014825 | Neuronal PAS domain protein 4. | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. | 0.400 |
| NPAS4 | UTP15 | ENSPPYP00000003503 | ENSPPYP00000017381 | Neuronal PAS domain protein 4. | U3 small nucleolar RNA-associated protein 15 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. | 0.700 |
| PSMD1 | DUSP26 | ENSPPYP00000014825 | ENSPPYP00000020739 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.424 |
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