node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCKDHB | DLAT | ENSPPYP00000018803 | ENSPPYP00000004435 | BCKDHB isoform 1. | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.923 |
BCKDHB | DLD | ENSPPYP00000018803 | ENSPPYP00000020072 | BCKDHB isoform 1. | Dihydrolipoyl dehydrogenase, mitochondrial; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched- chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT [...] | 0.995 |
BCKDHB | LDHA | ENSPPYP00000018803 | ENSPPYP00000003946 | BCKDHB isoform 1. | L-lactate dehydrogenase A chain. | 0.928 |
BCKDHB | PC | ENSPPYP00000018803 | ENSPPYP00000003482 | BCKDHB isoform 1. | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.440 |
BCKDHB | PDHA1 | ENSPPYP00000018803 | ENSPPYP00000022568 | BCKDHB isoform 1. | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. | 0.958 |
BCKDHB | PDHB | ENSPPYP00000018803 | ENSPPYP00000015393 | BCKDHB isoform 1. | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. | 0.640 |
BCKDHB | PDHX | ENSPPYP00000018803 | ENSPPYP00000003859 | BCKDHB isoform 1. | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | 0.929 |
BCKDHB | PDK1 | ENSPPYP00000018803 | ENSPPYP00000014441 | BCKDHB isoform 1. | Protein-serine/threonine kinase. | 0.575 |
BCKDHB | PDK3 | ENSPPYP00000018803 | ENSPPYP00000022600 | BCKDHB isoform 1. | Protein-serine/threonine kinase. | 0.575 |
BCKDHB | PKM | ENSPPYP00000018803 | ENSPPYP00000007498 | BCKDHB isoform 1. | Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (By similarity). Stimulates POU5F1-mediated transcriptional activation (By similarity). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity). | 0.511 |
DLAT | BCKDHB | ENSPPYP00000004435 | ENSPPYP00000018803 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | BCKDHB isoform 1. | 0.923 |
DLAT | DLD | ENSPPYP00000004435 | ENSPPYP00000020072 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Dihydrolipoyl dehydrogenase, mitochondrial; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched- chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT [...] | 0.999 |
DLAT | PC | ENSPPYP00000004435 | ENSPPYP00000003482 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.870 |
DLAT | PDHA1 | ENSPPYP00000004435 | ENSPPYP00000022568 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. | 0.999 |
DLAT | PDHB | ENSPPYP00000004435 | ENSPPYP00000015393 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. | 0.999 |
DLAT | PDHX | ENSPPYP00000004435 | ENSPPYP00000003859 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | 0.996 |
DLAT | PDK1 | ENSPPYP00000004435 | ENSPPYP00000014441 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Protein-serine/threonine kinase. | 0.689 |
DLAT | PDK3 | ENSPPYP00000004435 | ENSPPYP00000022600 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Protein-serine/threonine kinase. | 0.962 |
DLAT | PKM | ENSPPYP00000004435 | ENSPPYP00000007498 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (By similarity). Stimulates POU5F1-mediated transcriptional activation (By similarity). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity). | 0.414 |
DLD | BCKDHB | ENSPPYP00000020072 | ENSPPYP00000018803 | Dihydrolipoyl dehydrogenase, mitochondrial; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched- chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT [...] | BCKDHB isoform 1. | 0.995 |