node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADGRD1 | CSE1L | ENSPPYP00000005843 | ENSPPYP00000023647 | ADGRD1 isoform 4; Belongs to the G-protein coupled receptor 2 family. | Exportin-2; Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause releas [...] | 0.789 |
ADGRD1 | ENSPPYP00000020348 | ENSPPYP00000005843 | ENSPPYP00000020348 | ADGRD1 isoform 4; Belongs to the G-protein coupled receptor 2 family. | annotation not available | 0.436 |
ADGRD1 | KPNA1 | ENSPPYP00000005843 | ENSPPYP00000015082 | ADGRD1 isoform 4; Belongs to the G-protein coupled receptor 2 family. | Importin subunit alpha-5, N-terminally processed; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and impo [...] | 0.431 |
ADGRD1 | KPNA2 | ENSPPYP00000005843 | ENSPPYP00000009624 | ADGRD1 isoform 4; Belongs to the G-protein coupled receptor 2 family. | Importin subunit alpha; Functions in nuclear protein import. | 0.436 |
ADGRD1 | KPNA3 | ENSPPYP00000005843 | ENSPPYP00000006120 | ADGRD1 isoform 4; Belongs to the G-protein coupled receptor 2 family. | Importin subunit alpha; Functions in nuclear protein import. | 0.431 |
ADGRD1 | KPNA4 | ENSPPYP00000005843 | ENSPPYP00000015939 | ADGRD1 isoform 4; Belongs to the G-protein coupled receptor 2 family. | Importin subunit alpha; Functions in nuclear protein import. | 0.431 |
ADGRD1 | NUP50 | ENSPPYP00000005843 | ENSPPYP00000013314 | ADGRD1 isoform 4; Belongs to the G-protein coupled receptor 2 family. | NUP50 isoform 1. | 0.749 |
ADGRD1 | XPO1 | ENSPPYP00000005843 | ENSPPYP00000013810 | ADGRD1 isoform 4; Belongs to the G-protein coupled receptor 2 family. | XPO1 isoform 9. | 0.899 |
ADGRD1 | XPO4 | ENSPPYP00000005843 | ENSPPYP00000005919 | ADGRD1 isoform 4; Belongs to the G-protein coupled receptor 2 family. | XPO4 isoform 1. | 0.428 |
CSE1L | ADGRD1 | ENSPPYP00000023647 | ENSPPYP00000005843 | Exportin-2; Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause releas [...] | ADGRD1 isoform 4; Belongs to the G-protein coupled receptor 2 family. | 0.789 |
CSE1L | ENSPPYP00000020348 | ENSPPYP00000023647 | ENSPPYP00000020348 | Exportin-2; Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause releas [...] | annotation not available | 0.700 |
CSE1L | KPNA1 | ENSPPYP00000023647 | ENSPPYP00000015082 | Exportin-2; Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause releas [...] | Importin subunit alpha-5, N-terminally processed; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and impo [...] | 0.977 |
CSE1L | KPNA2 | ENSPPYP00000023647 | ENSPPYP00000009624 | Exportin-2; Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause releas [...] | Importin subunit alpha; Functions in nuclear protein import. | 0.700 |
CSE1L | KPNA3 | ENSPPYP00000023647 | ENSPPYP00000006120 | Exportin-2; Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause releas [...] | Importin subunit alpha; Functions in nuclear protein import. | 0.963 |
CSE1L | KPNA4 | ENSPPYP00000023647 | ENSPPYP00000015939 | Exportin-2; Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause releas [...] | Importin subunit alpha; Functions in nuclear protein import. | 0.970 |
CSE1L | NUP50 | ENSPPYP00000023647 | ENSPPYP00000013314 | Exportin-2; Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause releas [...] | NUP50 isoform 1. | 0.717 |
CSE1L | RAN | ENSPPYP00000023647 | ENSPPYP00000005841 | Exportin-2; Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause releas [...] | GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...] | 0.817 |
CSE1L | XPO1 | ENSPPYP00000023647 | ENSPPYP00000013810 | Exportin-2; Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause releas [...] | XPO1 isoform 9. | 0.842 |
CSE1L | XPO4 | ENSPPYP00000023647 | ENSPPYP00000005919 | Exportin-2; Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause releas [...] | XPO4 isoform 1. | 0.679 |
ENSPPYP00000020348 | ADGRD1 | ENSPPYP00000020348 | ENSPPYP00000005843 | annotation not available | ADGRD1 isoform 4; Belongs to the G-protein coupled receptor 2 family. | 0.436 |