node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARPP19 | ARPP21 | ENSP00000454341 | ENSP00000412326 | cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. Belongs to the endosulfine family. | cAMP-regulated phosphoprotein 21; Isoform 2 may act as a competitive inhibitor of calmodulin- dependent enzymes such as calcineurin in neurons. | 0.890 |
ARPP19 | ENSA | ENSP00000454341 | ENSP00000341743 | cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. Belongs to the endosulfine family. | Alpha-endosulfine; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. | 0.565 |
ARPP19 | PPP1R1B | ENSP00000454341 | ENSP00000254079 | cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. Belongs to the endosulfine family. | Protein phosphatase 1 regulatory subunit 1B; Inhibitor of protein-phosphatase 1. | 0.799 |
ARPP21 | ARPP19 | ENSP00000412326 | ENSP00000454341 | cAMP-regulated phosphoprotein 21; Isoform 2 may act as a competitive inhibitor of calmodulin- dependent enzymes such as calcineurin in neurons. | cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. Belongs to the endosulfine family. | 0.890 |
ARPP21 | BCL11B | ENSP00000412326 | ENSP00000349723 | cAMP-regulated phosphoprotein 21; Isoform 2 may act as a competitive inhibitor of calmodulin- dependent enzymes such as calcineurin in neurons. | B-cell lymphoma/leukemia 11B; Key regulator of both differentiation and survival of T- lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus. Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes. Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element [...] | 0.530 |
ARPP21 | CAMK1 | ENSP00000412326 | ENSP00000256460 | cAMP-regulated phosphoprotein 21; Isoform 2 may act as a competitive inhibitor of calmodulin- dependent enzymes such as calcineurin in neurons. | Calcium/calmodulin-dependent protein kinase type 1; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in h [...] | 0.642 |
ARPP21 | CAMK2A | ENSP00000412326 | ENSP00000500386 | cAMP-regulated phosphoprotein 21; Isoform 2 may act as a competitive inhibitor of calmodulin- dependent enzymes such as calcineurin in neurons. | Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcriptio [...] | 0.555 |
ARPP21 | DRD1 | ENSP00000412326 | ENSP00000377353 | cAMP-regulated phosphoprotein 21; Isoform 2 may act as a competitive inhibitor of calmodulin- dependent enzymes such as calcineurin in neurons. | D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | 0.532 |
ARPP21 | ENSA | ENSP00000412326 | ENSP00000341743 | cAMP-regulated phosphoprotein 21; Isoform 2 may act as a competitive inhibitor of calmodulin- dependent enzymes such as calcineurin in neurons. | Alpha-endosulfine; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. | 0.670 |
ARPP21 | PCP4 | ENSP00000412326 | ENSP00000329403 | cAMP-regulated phosphoprotein 21; Isoform 2 may act as a competitive inhibitor of calmodulin- dependent enzymes such as calcineurin in neurons. | Calmodulin regulator protein PCP4; Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls. For instance, may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling pathways. Belongs to the PCP4 family. | 0.554 |
ARPP21 | PPP1R1B | ENSP00000412326 | ENSP00000254079 | cAMP-regulated phosphoprotein 21; Isoform 2 may act as a competitive inhibitor of calmodulin- dependent enzymes such as calcineurin in neurons. | Protein phosphatase 1 regulatory subunit 1B; Inhibitor of protein-phosphatase 1. | 0.844 |
ARPP21 | SLC6A1 | ENSP00000412326 | ENSP00000494136 | cAMP-regulated phosphoprotein 21; Isoform 2 may act as a competitive inhibitor of calmodulin- dependent enzymes such as calcineurin in neurons. | Sodium- and chloride-dependent GABA transporter 1; Terminates the action of GABA by its high affinity sodium- dependent reuptake into presynaptic terminals. | 0.543 |
ARPP21 | SV2B | ENSP00000412326 | ENSP00000377779 | cAMP-regulated phosphoprotein 21; Isoform 2 may act as a competitive inhibitor of calmodulin- dependent enzymes such as calcineurin in neurons. | Synaptic vesicle glycoprotein 2B; Probably plays a role in the control of regulated secretion in neural and endocrine cells. | 0.523 |
BCL11B | ARPP21 | ENSP00000349723 | ENSP00000412326 | B-cell lymphoma/leukemia 11B; Key regulator of both differentiation and survival of T- lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus. Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes. Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element [...] | cAMP-regulated phosphoprotein 21; Isoform 2 may act as a competitive inhibitor of calmodulin- dependent enzymes such as calcineurin in neurons. | 0.530 |
BCL11B | DRD1 | ENSP00000349723 | ENSP00000377353 | B-cell lymphoma/leukemia 11B; Key regulator of both differentiation and survival of T- lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus. Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes. Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element [...] | D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | 0.466 |
BCL11B | PPP1R1B | ENSP00000349723 | ENSP00000254079 | B-cell lymphoma/leukemia 11B; Key regulator of both differentiation and survival of T- lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus. Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes. Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element [...] | Protein phosphatase 1 regulatory subunit 1B; Inhibitor of protein-phosphatase 1. | 0.572 |
CAMK1 | ARPP21 | ENSP00000256460 | ENSP00000412326 | Calcium/calmodulin-dependent protein kinase type 1; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in h [...] | cAMP-regulated phosphoprotein 21; Isoform 2 may act as a competitive inhibitor of calmodulin- dependent enzymes such as calcineurin in neurons. | 0.642 |
CAMK2A | ARPP21 | ENSP00000500386 | ENSP00000412326 | Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcriptio [...] | cAMP-regulated phosphoprotein 21; Isoform 2 may act as a competitive inhibitor of calmodulin- dependent enzymes such as calcineurin in neurons. | 0.555 |
CAMK2A | DRD1 | ENSP00000500386 | ENSP00000377353 | Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcriptio [...] | D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | 0.507 |
CAMK2A | PPP1R1B | ENSP00000500386 | ENSP00000254079 | Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcriptio [...] | Protein phosphatase 1 regulatory subunit 1B; Inhibitor of protein-phosphatase 1. | 0.439 |