STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCDC198Uncharacterized protein CCDC198; Coiled-coil domain containing 198. (336 aa)    
Predicted Functional Partners:
SLC35F4
Solute carrier family 35 member F4; Putative solute transporter.
   
  
 0.644
OR10G6
Olfactory receptor 10G6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.615
AMPD2
AMP deaminase 2; AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.
    
   0.545
OR8B8
Olfactory receptor 8B8; Odorant receptor (Potential). May be involved in taste perception.
      
 0.487
FHL5
Four and a half LIM domains protein 5; May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation- independent manner.
   
   0.481
JADE2
E3 ubiquitin-protein ligase Jade-2; Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Acts as a E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A. Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity).
      
 0.479
ANKRD18B
Ankyrin repeat domain 18B.
      
 0.478
PM20D2
Peptidase M20 domain containing 2.
      
 0.446
DEFB130A
Beta-defensin 130A; Antimicrobial host-defense peptide. Has an antiplasmodial activity.
      
 0.445
ARMH4
Armadillo-like helical domain-containing protein 4; Armadillo like helical domain containing 4.
   
  
 0.403
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.