node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC141 | CCSER2 | ENSP00000386503 | ENSP00000361160 | Coiled-coil domain-containing protein 141; Plays a critical role in radial migration and centrosomal function. | Serine-rich coiled-coil domain-containing protein 2; Microtubule-binding protein which might play a role in microtubule bundling. | 0.460 |
CCSER2 | CCDC141 | ENSP00000361160 | ENSP00000386503 | Serine-rich coiled-coil domain-containing protein 2; Microtubule-binding protein which might play a role in microtubule bundling. | Coiled-coil domain-containing protein 141; Plays a critical role in radial migration and centrosomal function. | 0.460 |
CCSER2 | DYDC1 | ENSP00000361160 | ENSP00000361278 | Serine-rich coiled-coil domain-containing protein 2; Microtubule-binding protein which might play a role in microtubule bundling. | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | 0.555 |
CCSER2 | DYDC2 | ENSP00000361160 | ENSP00000361272 | Serine-rich coiled-coil domain-containing protein 2; Microtubule-binding protein which might play a role in microtubule bundling. | DPY30 domain containing 2; Belongs to the dpy-30 family. | 0.483 |
CCSER2 | LUZP1 | ENSP00000361160 | ENSP00000303758 | Serine-rich coiled-coil domain-containing protein 2; Microtubule-binding protein which might play a role in microtubule bundling. | Leucine zipper protein 1. | 0.444 |
CCSER2 | NDE1 | ENSP00000361160 | ENSP00000379643 | Serine-rich coiled-coil domain-containing protein 2; Microtubule-binding protein which might play a role in microtubule bundling. | Nuclear distribution protein nudE homolog 1; Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neurona [...] | 0.514 |
CCSER2 | NDEL1 | ENSP00000361160 | ENSP00000333982 | Serine-rich coiled-coil domain-containing protein 2; Microtubule-binding protein which might play a role in microtubule bundling. | Nuclear distribution protein nudE-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripe [...] | 0.825 |
CCSER2 | PUM1 | ENSP00000361160 | ENSP00000391723 | Serine-rich coiled-coil domain-containing protein 2; Microtubule-binding protein which might play a role in microtubule bundling. | Pumilio homolog 1; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Following growth [...] | 0.460 |
CCSER2 | SYMPK | ENSP00000361160 | ENSP00000245934 | Serine-rich coiled-coil domain-containing protein 2; Microtubule-binding protein which might play a role in microtubule bundling. | Symplekin; Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. | 0.443 |
CCSER2 | SYNE1 | ENSP00000361160 | ENSP00000356224 | Serine-rich coiled-coil domain-containing protein 2; Microtubule-binding protein which might play a role in microtubule bundling. | Nesprin-1; Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus- centrosome attachment and nuclear migrati [...] | 0.504 |
CCSER2 | TSPAN14 | ENSP00000361160 | ENSP00000361231 | Serine-rich coiled-coil domain-containing protein 2; Microtubule-binding protein which might play a role in microtubule bundling. | Tetraspanin-14; Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity). | 0.458 |
DYDC1 | CCSER2 | ENSP00000361278 | ENSP00000361160 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | Serine-rich coiled-coil domain-containing protein 2; Microtubule-binding protein which might play a role in microtubule bundling. | 0.555 |
DYDC1 | DYDC2 | ENSP00000361278 | ENSP00000361272 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | DPY30 domain containing 2; Belongs to the dpy-30 family. | 0.712 |
DYDC1 | TSPAN14 | ENSP00000361278 | ENSP00000361231 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | Tetraspanin-14; Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity). | 0.643 |
DYDC2 | CCSER2 | ENSP00000361272 | ENSP00000361160 | DPY30 domain containing 2; Belongs to the dpy-30 family. | Serine-rich coiled-coil domain-containing protein 2; Microtubule-binding protein which might play a role in microtubule bundling. | 0.483 |
DYDC2 | DYDC1 | ENSP00000361272 | ENSP00000361278 | DPY30 domain containing 2; Belongs to the dpy-30 family. | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | 0.712 |
DYDC2 | TSPAN14 | ENSP00000361272 | ENSP00000361231 | DPY30 domain containing 2; Belongs to the dpy-30 family. | Tetraspanin-14; Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity). | 0.611 |
LUZP1 | CCSER2 | ENSP00000303758 | ENSP00000361160 | Leucine zipper protein 1. | Serine-rich coiled-coil domain-containing protein 2; Microtubule-binding protein which might play a role in microtubule bundling. | 0.444 |
NDE1 | CCSER2 | ENSP00000379643 | ENSP00000361160 | Nuclear distribution protein nudE homolog 1; Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neurona [...] | Serine-rich coiled-coil domain-containing protein 2; Microtubule-binding protein which might play a role in microtubule bundling. | 0.514 |
NDE1 | NDEL1 | ENSP00000379643 | ENSP00000333982 | Nuclear distribution protein nudE homolog 1; Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neurona [...] | Nuclear distribution protein nudE-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripe [...] | 0.982 |