node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACSS1 | CSTL1 | ENSP00000316924 | ENSP00000344907 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (By similarity). Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (By similarity). | Cystatin like 1. | 0.407 |
ACSS1 | GZF1 | ENSP00000316924 | ENSP00000338290 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (By similarity). Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (By similarity). | GDNF-inducible zinc finger protein 1; Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression. | 0.407 |
CST11 | CST9 | ENSP00000366208 | ENSP00000366170 | Cystatin-11; Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization. Belongs to the cystatin family. | Cystatin-9; May be involved in testis development (By similarity). May play a role in hematopoietic differentiation or inflammation. Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria ; Belongs to the cystatin family. | 0.613 |
CST11 | CSTL1 | ENSP00000366208 | ENSP00000344907 | Cystatin-11; Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization. Belongs to the cystatin family. | Cystatin like 1. | 0.488 |
CST11 | GZF1 | ENSP00000366208 | ENSP00000338290 | Cystatin-11; Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization. Belongs to the cystatin family. | GDNF-inducible zinc finger protein 1; Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression. | 0.456 |
CST11 | NXT1 | ENSP00000366208 | ENSP00000254998 | Cystatin-11; Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization. Belongs to the cystatin family. | NTF2-related export protein 1; Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5. | 0.405 |
CST3 | CST9 | ENSP00000381448 | ENSP00000366170 | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family. | Cystatin-9; May be involved in testis development (By similarity). May play a role in hematopoietic differentiation or inflammation. Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria ; Belongs to the cystatin family. | 0.563 |
CST3 | CSTL1 | ENSP00000381448 | ENSP00000344907 | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family. | Cystatin like 1. | 0.420 |
CST3 | CTSB | ENSP00000381448 | ENSP00000345672 | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family. | Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis. Belongs to the peptidase C1 family. | 0.982 |
CST9 | CST11 | ENSP00000366170 | ENSP00000366208 | Cystatin-9; May be involved in testis development (By similarity). May play a role in hematopoietic differentiation or inflammation. Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria ; Belongs to the cystatin family. | Cystatin-11; Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization. Belongs to the cystatin family. | 0.613 |
CST9 | CST3 | ENSP00000366170 | ENSP00000381448 | Cystatin-9; May be involved in testis development (By similarity). May play a role in hematopoietic differentiation or inflammation. Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria ; Belongs to the cystatin family. | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family. | 0.563 |
CST9 | CSTL1 | ENSP00000366170 | ENSP00000344907 | Cystatin-9; May be involved in testis development (By similarity). May play a role in hematopoietic differentiation or inflammation. Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria ; Belongs to the cystatin family. | Cystatin like 1. | 0.600 |
CSTL1 | ACSS1 | ENSP00000344907 | ENSP00000316924 | Cystatin like 1. | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (By similarity). Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (By similarity). | 0.407 |
CSTL1 | CST11 | ENSP00000344907 | ENSP00000366208 | Cystatin like 1. | Cystatin-11; Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization. Belongs to the cystatin family. | 0.488 |
CSTL1 | CST3 | ENSP00000344907 | ENSP00000381448 | Cystatin like 1. | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family. | 0.420 |
CSTL1 | CST9 | ENSP00000344907 | ENSP00000366170 | Cystatin like 1. | Cystatin-9; May be involved in testis development (By similarity). May play a role in hematopoietic differentiation or inflammation. Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria ; Belongs to the cystatin family. | 0.600 |
CSTL1 | CTSB | ENSP00000344907 | ENSP00000345672 | Cystatin like 1. | Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis. Belongs to the peptidase C1 family. | 0.428 |
CSTL1 | GZF1 | ENSP00000344907 | ENSP00000338290 | Cystatin like 1. | GDNF-inducible zinc finger protein 1; Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression. | 0.511 |
CSTL1 | IQCF6 | ENSP00000344907 | ENSP00000381760 | Cystatin like 1. | IQ motif containing F6. | 0.496 |
CSTL1 | NXT1 | ENSP00000344907 | ENSP00000254998 | Cystatin like 1. | NTF2-related export protein 1; Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5. | 0.452 |