node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARF3 | CHML | ENSP00000256682 | ENSP00000355511 | ADP-ribosylation factor 3; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus; Belongs to the small GTPase superfamily. Arf family. | Rab proteins geranylgeranyltransferase component A 2; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family. | 0.456 |
ARF3 | RAB30 | ENSP00000256682 | ENSP00000435189 | ADP-ribosylation factor 3; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus; Belongs to the small GTPase superfamily. Arf family. | Ras-related protein Rab-30; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins. | 0.666 |
CHM | CHML | ENSP00000350386 | ENSP00000355511 | Rab proteins geranylgeranyltransferase component A 1; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative [...] | Rab proteins geranylgeranyltransferase component A 2; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family. | 0.736 |
CHM | RAB30 | ENSP00000350386 | ENSP00000435189 | Rab proteins geranylgeranyltransferase component A 1; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative [...] | Ras-related protein Rab-30; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins. | 0.676 |
CHML | ARF3 | ENSP00000355511 | ENSP00000256682 | Rab proteins geranylgeranyltransferase component A 2; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family. | ADP-ribosylation factor 3; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus; Belongs to the small GTPase superfamily. Arf family. | 0.456 |
CHML | CHM | ENSP00000355511 | ENSP00000350386 | Rab proteins geranylgeranyltransferase component A 2; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family. | Rab proteins geranylgeranyltransferase component A 1; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative [...] | 0.736 |
CHML | RAB30 | ENSP00000355511 | ENSP00000435189 | Rab proteins geranylgeranyltransferase component A 2; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family. | Ras-related protein Rab-30; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins. | 0.667 |
COG1 | COG2 | ENSP00000299886 | ENSP00000355629 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | 0.999 |
COG1 | COG3 | ENSP00000299886 | ENSP00000258654 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | 0.999 |
COG1 | COG4 | ENSP00000299886 | ENSP00000315775 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. Belongs to the COG4 family. | 0.999 |
COG1 | COG6 | ENSP00000299886 | ENSP00000397441 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Belongs to the COG6 family. | 0.999 |
COG1 | COG8 | ENSP00000299886 | ENSP00000497669 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | 0.999 |
COG1 | GCC2 | ENSP00000299886 | ENSP00000307939 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2. | 0.660 |
COG1 | RAB30 | ENSP00000299886 | ENSP00000435189 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | Ras-related protein Rab-30; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins. | 0.644 |
COG2 | COG1 | ENSP00000355629 | ENSP00000299886 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function. | 0.999 |
COG2 | COG3 | ENSP00000355629 | ENSP00000258654 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | 0.999 |
COG2 | COG4 | ENSP00000355629 | ENSP00000315775 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. Belongs to the COG4 family. | 0.999 |
COG2 | COG6 | ENSP00000355629 | ENSP00000397441 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Belongs to the COG6 family. | 0.999 |
COG2 | COG8 | ENSP00000355629 | ENSP00000497669 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | 0.999 |
COG2 | GCC2 | ENSP00000355629 | ENSP00000307939 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family. | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2. | 0.617 |