node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC24 | WDR89 | ENSP00000361392 | ENSP00000378399 | Coiled-coil domain containing 24. | WD repeat domain 89. | 0.498 |
MTERF1 | WDR89 | ENSP00000248643 | ENSP00000378399 | Transcription termination factor 1, mitochondrial; Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand; Belongs to the mTERF family. | WD repeat domain 89. | 0.635 |
NOL8 | RPL10A | ENSP00000441140 | ENSP00000363018 | Nucleolar protein 8; Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post- transcriptional level or in ribosome biogenesis in cancer cells. | 60S ribosomal protein L10a; Component of the large ribosomal subunit. | 0.660 |
NOL8 | SDAD1 | ENSP00000441140 | ENSP00000348596 | Nucleolar protein 8; Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post- transcriptional level or in ribosome biogenesis in cancer cells. | Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. | 0.838 |
NOL8 | WDR89 | ENSP00000441140 | ENSP00000378399 | Nucleolar protein 8; Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post- transcriptional level or in ribosome biogenesis in cancer cells. | WD repeat domain 89. | 0.727 |
RPF2 | SDAD1 | ENSP00000402338 | ENSP00000348596 | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. | Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. | 0.967 |
RPF2 | UTP3 | ENSP00000402338 | ENSP00000254803 | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. | Something about silencing protein 10; Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity); Belongs to the SAS10 family. | 0.922 |
RPF2 | WDR36 | ENSP00000402338 | ENSP00000423067 | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. | WD repeat-containing protein 36; Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2. | 0.941 |
RPF2 | WDR43 | ENSP00000402338 | ENSP00000384302 | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. | WD repeat-containing protein 43; Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its t [...] | 0.927 |
RPF2 | WDR75 | ENSP00000402338 | ENSP00000314193 | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. | WD repeat-containing protein 75; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. | 0.925 |
RPF2 | WDR89 | ENSP00000402338 | ENSP00000378399 | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. | WD repeat domain 89. | 0.496 |
RPL10A | NOL8 | ENSP00000363018 | ENSP00000441140 | 60S ribosomal protein L10a; Component of the large ribosomal subunit. | Nucleolar protein 8; Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post- transcriptional level or in ribosome biogenesis in cancer cells. | 0.660 |
RPL10A | SDAD1 | ENSP00000363018 | ENSP00000348596 | 60S ribosomal protein L10a; Component of the large ribosomal subunit. | Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. | 0.426 |
RPL10A | WDR89 | ENSP00000363018 | ENSP00000378399 | 60S ribosomal protein L10a; Component of the large ribosomal subunit. | WD repeat domain 89. | 0.560 |
SDAD1 | NOL8 | ENSP00000348596 | ENSP00000441140 | Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. | Nucleolar protein 8; Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post- transcriptional level or in ribosome biogenesis in cancer cells. | 0.838 |
SDAD1 | RPF2 | ENSP00000348596 | ENSP00000402338 | Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. | 0.967 |
SDAD1 | RPL10A | ENSP00000348596 | ENSP00000363018 | Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. | 60S ribosomal protein L10a; Component of the large ribosomal subunit. | 0.426 |
SDAD1 | UTP3 | ENSP00000348596 | ENSP00000254803 | Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. | Something about silencing protein 10; Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity); Belongs to the SAS10 family. | 0.891 |
SDAD1 | WDR36 | ENSP00000348596 | ENSP00000423067 | Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. | WD repeat-containing protein 36; Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2. | 0.928 |
SDAD1 | WDR43 | ENSP00000348596 | ENSP00000384302 | Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. | WD repeat-containing protein 43; Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its t [...] | 0.954 |