STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRTCAP3Keratinocyte associated protein 3. (240 aa)    
Predicted Functional Partners:
CCDC121
Coiled-coil domain containing 121.
      
 0.654
NRBP1
Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
 
    
 0.626
ZNF512
Zinc finger protein 512; May be involved in transcriptional regulation.
      
 0.604
TTC22
Tetratricopeptide repeat domain 22.
   
  
 0.591
FNDC4
Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis.
      
 0.564
ZNF513
Zinc finger protein 513; Transcriptional regulator that plays a role in retinal development and maintenance.
   
  
 0.529
ZNF888
Zinc finger protein 888; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
      
 0.527
SPATC1L
Speriolin-like protein; Spermatogenesis and centriole associated 1 like.
      
 0.510
TSPEAR
Thrombospondin-type laminin G domain and EAR repeat-containing protein; Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. May play a role in development or function of the auditory system.
      
 0.504
GTF3C2
General transcription factor 3C polypeptide 2; Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1.
      
 0.473
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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