node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C3orf67 | PLEKHN1 | ENSP00000295966 | ENSP00000368720 | Uncharacterized protein C3orf67. | Pleckstrin homology domain-containing family N member 1; Controls the stability of the leptin mRNA harboring an AU- rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1. Decreases the stability of the leptin mRNA by antagonizing the function of ELAVL1 by inducing its atypical recruitment from the nucleus to the cytosol (By similarity). Binds to cardiolipin (CL), phosphatidic acid (PA), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidylserine (PS). Promotes apoptosis by enhancing BAX-BAK hetero-oligomerization via interaction with BID in colon canc [...] | 0.559 |
C3orf67 | PTPDC1 | ENSP00000295966 | ENSP00000477817 | Uncharacterized protein C3orf67. | Protein tyrosine phosphatase domain-containing protein 1; May play roles in cilia formation and/or maintenance. Belongs to the protein-tyrosine phosphatase family. Non- receptor class PTPDC1 subfamily. | 0.475 |
CCDC73 | ERCC6L | ENSP00000335325 | ENSP00000334675 | Coiled-coil domain containing 73. | DNA excision repair protein ERCC-6-like; DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro). | 0.455 |
CCDC73 | KLK9 | ENSP00000335325 | ENSP00000469417 | Coiled-coil domain containing 73. | Kallikrein-9; Kallikrein related peptidase 9. | 0.492 |
CCDC73 | PTPDC1 | ENSP00000335325 | ENSP00000477817 | Coiled-coil domain containing 73. | Protein tyrosine phosphatase domain-containing protein 1; May play roles in cilia formation and/or maintenance. Belongs to the protein-tyrosine phosphatase family. Non- receptor class PTPDC1 subfamily. | 0.534 |
ERCC6L | CCDC73 | ENSP00000334675 | ENSP00000335325 | DNA excision repair protein ERCC-6-like; DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro). | Coiled-coil domain containing 73. | 0.455 |
ERCC6L | KLK9 | ENSP00000334675 | ENSP00000469417 | DNA excision repair protein ERCC-6-like; DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro). | Kallikrein-9; Kallikrein related peptidase 9. | 0.428 |
ERCC6L | PTPDC1 | ENSP00000334675 | ENSP00000477817 | DNA excision repair protein ERCC-6-like; DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro). | Protein tyrosine phosphatase domain-containing protein 1; May play roles in cilia formation and/or maintenance. Belongs to the protein-tyrosine phosphatase family. Non- receptor class PTPDC1 subfamily. | 0.524 |
IPPK | PTPDC1 | ENSP00000287996 | ENSP00000477817 | Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis; Belongs to the IPK1 type 2 family. | Protein tyrosine phosphatase domain-containing protein 1; May play roles in cilia formation and/or maintenance. Belongs to the protein-tyrosine phosphatase family. Non- receptor class PTPDC1 subfamily. | 0.484 |
KLK9 | CCDC73 | ENSP00000469417 | ENSP00000335325 | Kallikrein-9; Kallikrein related peptidase 9. | Coiled-coil domain containing 73. | 0.492 |
KLK9 | ERCC6L | ENSP00000469417 | ENSP00000334675 | Kallikrein-9; Kallikrein related peptidase 9. | DNA excision repair protein ERCC-6-like; DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro). | 0.428 |
KLK9 | PTPDC1 | ENSP00000469417 | ENSP00000477817 | Kallikrein-9; Kallikrein related peptidase 9. | Protein tyrosine phosphatase domain-containing protein 1; May play roles in cilia formation and/or maintenance. Belongs to the protein-tyrosine phosphatase family. Non- receptor class PTPDC1 subfamily. | 0.475 |
PLEKHN1 | C3orf67 | ENSP00000368720 | ENSP00000295966 | Pleckstrin homology domain-containing family N member 1; Controls the stability of the leptin mRNA harboring an AU- rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1. Decreases the stability of the leptin mRNA by antagonizing the function of ELAVL1 by inducing its atypical recruitment from the nucleus to the cytosol (By similarity). Binds to cardiolipin (CL), phosphatidic acid (PA), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidylserine (PS). Promotes apoptosis by enhancing BAX-BAK hetero-oligomerization via interaction with BID in colon canc [...] | Uncharacterized protein C3orf67. | 0.559 |
PLEKHN1 | PTPDC1 | ENSP00000368720 | ENSP00000477817 | Pleckstrin homology domain-containing family N member 1; Controls the stability of the leptin mRNA harboring an AU- rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1. Decreases the stability of the leptin mRNA by antagonizing the function of ELAVL1 by inducing its atypical recruitment from the nucleus to the cytosol (By similarity). Binds to cardiolipin (CL), phosphatidic acid (PA), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidylserine (PS). Promotes apoptosis by enhancing BAX-BAK hetero-oligomerization via interaction with BID in colon canc [...] | Protein tyrosine phosphatase domain-containing protein 1; May play roles in cilia formation and/or maintenance. Belongs to the protein-tyrosine phosphatase family. Non- receptor class PTPDC1 subfamily. | 0.470 |
PPP2CA | PPP2R1B | ENSP00000418447 | ENSP00000311344 | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. | 0.999 |
PPP2CA | PPP2R2A | ENSP00000418447 | ENSP00000325074 | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | 0.999 |
PPP2CA | PPP2R2D | ENSP00000418447 | ENSP00000399970 | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also ma [...] | 0.999 |
PPP2CA | PTPDC1 | ENSP00000418447 | ENSP00000477817 | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. | Protein tyrosine phosphatase domain-containing protein 1; May play roles in cilia formation and/or maintenance. Belongs to the protein-tyrosine phosphatase family. Non- receptor class PTPDC1 subfamily. | 0.553 |
PPP2R1B | PPP2CA | ENSP00000311344 | ENSP00000418447 | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. | 0.999 |
PPP2R1B | PPP2R2A | ENSP00000311344 | ENSP00000325074 | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | 0.999 |