node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EMC3 | JAGN1 | ENSP00000245046 | ENSP00000496942 | ER membrane protein complex subunit 3. | Protein jagunal homolog 1; Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contri [...] | 0.442 |
EMC3 | PRRT3 | ENSP00000245046 | ENSP00000392511 | ER membrane protein complex subunit 3. | Proline rich transmembrane protein 3. | 0.433 |
FANCD2OS | PRRT3 | ENSP00000429608 | ENSP00000392511 | FANCD2 opposite strand. | Proline rich transmembrane protein 3. | 0.479 |
FANCD2OS | TATDN2 | ENSP00000429608 | ENSP00000287652 | FANCD2 opposite strand. | Putative deoxyribonuclease TATDN2; Putative deoxyribonuclease. | 0.446 |
JAGN1 | EMC3 | ENSP00000496942 | ENSP00000245046 | Protein jagunal homolog 1; Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contri [...] | ER membrane protein complex subunit 3. | 0.442 |
JAGN1 | PRRT3 | ENSP00000496942 | ENSP00000392511 | Protein jagunal homolog 1; Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contri [...] | Proline rich transmembrane protein 3. | 0.451 |
JAGN1 | TATDN2 | ENSP00000496942 | ENSP00000287652 | Protein jagunal homolog 1; Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contri [...] | Putative deoxyribonuclease TATDN2; Putative deoxyribonuclease. | 0.422 |
POLR3A | PRRT3 | ENSP00000361446 | ENSP00000392511 | DNA-directed RNA polymerase III subunit RPC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single- stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to pro [...] | Proline rich transmembrane protein 3. | 0.457 |
POLR3A | SPRTN | ENSP00000361446 | ENSP00000295050 | DNA-directed RNA polymerase III subunit RPC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single- stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to pro [...] | SprT-like domain-containing protein Spartan; Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to [...] | 0.460 |
PRRT2 | PRRT3 | ENSP00000456226 | ENSP00000392511 | Proline-rich transmembrane protein 2; As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation. | Proline rich transmembrane protein 3. | 0.517 |
PRRT3 | EMC3 | ENSP00000392511 | ENSP00000245046 | Proline rich transmembrane protein 3. | ER membrane protein complex subunit 3. | 0.433 |
PRRT3 | FANCD2OS | ENSP00000392511 | ENSP00000429608 | Proline rich transmembrane protein 3. | FANCD2 opposite strand. | 0.479 |
PRRT3 | JAGN1 | ENSP00000392511 | ENSP00000496942 | Proline rich transmembrane protein 3. | Protein jagunal homolog 1; Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contri [...] | 0.451 |
PRRT3 | POLR3A | ENSP00000392511 | ENSP00000361446 | Proline rich transmembrane protein 3. | DNA-directed RNA polymerase III subunit RPC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single- stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to pro [...] | 0.457 |
PRRT3 | PRRT2 | ENSP00000392511 | ENSP00000456226 | Proline rich transmembrane protein 3. | Proline-rich transmembrane protein 2; As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation. | 0.517 |
PRRT3 | SPRTN | ENSP00000392511 | ENSP00000295050 | Proline rich transmembrane protein 3. | SprT-like domain-containing protein Spartan; Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to [...] | 0.477 |
PRRT3 | TATDN2 | ENSP00000392511 | ENSP00000287652 | Proline rich transmembrane protein 3. | Putative deoxyribonuclease TATDN2; Putative deoxyribonuclease. | 0.579 |
PRRT3 | TEX51 | ENSP00000392511 | ENSP00000489776 | Proline rich transmembrane protein 3. | Testis-expressed protein 51; Testis expressed 51. | 0.581 |
PRRT3 | UBA52 | ENSP00000392511 | ENSP00000388107 | Proline rich transmembrane protein 3. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] | 0.627 |
PRRT3 | ZZEF1 | ENSP00000392511 | ENSP00000371051 | Proline rich transmembrane protein 3. | Zinc finger ZZ-type and EF-hand domain containing 1. | 0.466 |