STRINGSTRING
PRRC1 protein (human) - STRING interaction network
"PRRC1" - Proline-rich coiled-coil 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurence
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[Homology]
Score
PRRC1Proline-rich coiled-coil 1 (445 aa)    
Predicted Functional Partners:
RHOA
Ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated [...] (193 aa)
     
      0.778
PAFAH1B2
Platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa); Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit (229 aa)
       
      0.774
PSMG1
Proteasome (prosome, macropain) assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (288 aa)
       
      0.774
SHMT2
Serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism. Thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (PubMed-21876188). Interconversion of serine and glycine (PubMed-25619277). Associates with mitochondrial DNA (PubMed-18063578). Plays a role in the deubiquitination of target proteins as component of the BRISC complex (PubMed-24075985). Required for IFNAR1 deubiquitination by the BRISC complex (PubMed-24075985) (504 aa)
       
      0.608
CAPS2
Calcyphosine 2 (557 aa)
           
  0.455
RUSC2
RUN and SH3 domain containing 2 (1516 aa)
           
  0.453
KIAA1024L
KIAA1024-like (190 aa)
           
  0.426
HNRNPA1
Heterogeneous nuclear ribonucleoprotein A1; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication (372 aa)
     
      0.419
HARS
histidyl-tRNA synthetase; Cytoplasmic histidine--tRNA ligase (Probable). Plays a role in axon guidance (509 aa)
       
      0.417
RAB1A
RAB1A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone [...] (205 aa)
       
 
  0.417
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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