node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APOA1 | SERPINA1 | ENSP00000236850 | ENSP00000416066 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | Short peptide from AAT; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin; Belongs to the serpin family. | 0.927 |
APOA1 | ZNF558 | ENSP00000236850 | ENSP00000471277 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | Zinc finger protein 558; May be involved in transcriptional regulation. | 0.463 |
MBD3L1 | OR2Z1 | ENSP00000471575 | ENSP00000493322 | Methyl-CpG-binding domain protein 3-like 1; Transcriptional repressor. | Olfactory receptor 2Z1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.590 |
MBD3L1 | ZNF558 | ENSP00000471575 | ENSP00000471277 | Methyl-CpG-binding domain protein 3-like 1; Transcriptional repressor. | Zinc finger protein 558; May be involved in transcriptional regulation. | 0.481 |
OR2Z1 | MBD3L1 | ENSP00000493322 | ENSP00000471575 | Olfactory receptor 2Z1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Methyl-CpG-binding domain protein 3-like 1; Transcriptional repressor. | 0.590 |
OR2Z1 | ZNF558 | ENSP00000493322 | ENSP00000471277 | Olfactory receptor 2Z1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Zinc finger protein 558; May be involved in transcriptional regulation. | 0.635 |
RCBTB2 | ZNF558 | ENSP00000389910 | ENSP00000471277 | RCC1 and BTB domain containing protein 2. | Zinc finger protein 558; May be involved in transcriptional regulation. | 0.427 |
SERPINA1 | APOA1 | ENSP00000416066 | ENSP00000236850 | Short peptide from AAT; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin; Belongs to the serpin family. | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | 0.927 |
SERPINA1 | ZNF558 | ENSP00000416066 | ENSP00000471277 | Short peptide from AAT; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin; Belongs to the serpin family. | Zinc finger protein 558; May be involved in transcriptional regulation. | 0.452 |
SPATA18 | ZNF558 | ENSP00000295213 | ENSP00000471277 | Mitochondria-eating protein; Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade [...] | Zinc finger protein 558; May be involved in transcriptional regulation. | 0.478 |
TAF9B | ZNF558 | ENSP00000339917 | ENSP00000471277 | Transcription initiation factor TFIID subunit 9B; Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. | Zinc finger protein 558; May be involved in transcriptional regulation. | 0.438 |
TAF9B | ZZZ3 | ENSP00000339917 | ENSP00000359837 | Transcription initiation factor TFIID subunit 9B; Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. | ZZ-type zinc finger-containing protein 3; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. | 0.775 |
TRIM28 | ZNF558 | ENSP00000253024 | ENSP00000471277 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 558; May be involved in transcriptional regulation. | 0.580 |
TRIM61 | ZNF558 | ENSP00000332288 | ENSP00000471277 | Putative tripartite motif-containing protein 61; Tripartite motif containing 61. | Zinc finger protein 558; May be involved in transcriptional regulation. | 0.657 |
ZNF558 | APOA1 | ENSP00000471277 | ENSP00000236850 | Zinc finger protein 558; May be involved in transcriptional regulation. | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | 0.463 |
ZNF558 | MBD3L1 | ENSP00000471277 | ENSP00000471575 | Zinc finger protein 558; May be involved in transcriptional regulation. | Methyl-CpG-binding domain protein 3-like 1; Transcriptional repressor. | 0.481 |
ZNF558 | OR2Z1 | ENSP00000471277 | ENSP00000493322 | Zinc finger protein 558; May be involved in transcriptional regulation. | Olfactory receptor 2Z1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.635 |
ZNF558 | RCBTB2 | ENSP00000471277 | ENSP00000389910 | Zinc finger protein 558; May be involved in transcriptional regulation. | RCC1 and BTB domain containing protein 2. | 0.427 |
ZNF558 | SERPINA1 | ENSP00000471277 | ENSP00000416066 | Zinc finger protein 558; May be involved in transcriptional regulation. | Short peptide from AAT; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin; Belongs to the serpin family. | 0.452 |
ZNF558 | SPATA18 | ENSP00000471277 | ENSP00000295213 | Zinc finger protein 558; May be involved in transcriptional regulation. | Mitochondria-eating protein; Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade [...] | 0.478 |