node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LIPG | SLFN12 | ENSP00000261292 | ENSP00000378063 | Endothelial lipase; Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin; Belongs to the AB hydrolase superfamily. Lipase family. | Schlafen family member 12; Belongs to the Schlafen family. Subgroup II subfamily. | 0.400 |
LIPG | SOWAHC | ENSP00000261292 | ENSP00000365830 | Endothelial lipase; Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin; Belongs to the AB hydrolase superfamily. Lipase family. | Ankyrin repeat domain-containing protein SOWAHC; Sosondowah ankyrin repeat domain family member C; Belongs to the SOWAH family. | 0.464 |
PDE3A | SLFN12 | ENSP00000351957 | ENSP00000378063 | cGMP-inhibited 3',5'-cyclic phosphodiesterase A; Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. | Schlafen family member 12; Belongs to the Schlafen family. Subgroup II subfamily. | 0.973 |
PDLIM7 | SLFN12 | ENSP00000348099 | ENSP00000378063 | PDZ and LIM domain protein 7; May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). | Schlafen family member 12; Belongs to the Schlafen family. Subgroup II subfamily. | 0.447 |
SERPINB12 | SLFN12 | ENSP00000372218 | ENSP00000378063 | Serpin B12; Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator; Belongs to the serpin family. Ov-serpin subfamily. | Schlafen family member 12; Belongs to the Schlafen family. Subgroup II subfamily. | 0.506 |
SLC19A1 | SLFN12 | ENSP00000308895 | ENSP00000378063 | Reduced folate transporter; Transporter that mediates the import of reduced folates and a subset of cyclic dinucleotides. Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate. Also able to mediate the import of antifolate drug methotrexate. Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP. Mechanistically, acts as an antiporter, which export of intracellular organic anions to facilitate uptake of [...] | Schlafen family member 12; Belongs to the Schlafen family. Subgroup II subfamily. | 0.408 |
SLC19A1 | SOWAHC | ENSP00000308895 | ENSP00000365830 | Reduced folate transporter; Transporter that mediates the import of reduced folates and a subset of cyclic dinucleotides. Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate. Also able to mediate the import of antifolate drug methotrexate. Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP. Mechanistically, acts as an antiporter, which export of intracellular organic anions to facilitate uptake of [...] | Ankyrin repeat domain-containing protein SOWAHC; Sosondowah ankyrin repeat domain family member C; Belongs to the SOWAH family. | 0.422 |
SLFN12 | LIPG | ENSP00000378063 | ENSP00000261292 | Schlafen family member 12; Belongs to the Schlafen family. Subgroup II subfamily. | Endothelial lipase; Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin; Belongs to the AB hydrolase superfamily. Lipase family. | 0.400 |
SLFN12 | PDE3A | ENSP00000378063 | ENSP00000351957 | Schlafen family member 12; Belongs to the Schlafen family. Subgroup II subfamily. | cGMP-inhibited 3',5'-cyclic phosphodiesterase A; Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. | 0.973 |
SLFN12 | PDLIM7 | ENSP00000378063 | ENSP00000348099 | Schlafen family member 12; Belongs to the Schlafen family. Subgroup II subfamily. | PDZ and LIM domain protein 7; May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). | 0.447 |
SLFN12 | SERPINB12 | ENSP00000378063 | ENSP00000372218 | Schlafen family member 12; Belongs to the Schlafen family. Subgroup II subfamily. | Serpin B12; Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator; Belongs to the serpin family. Ov-serpin subfamily. | 0.506 |
SLFN12 | SLC19A1 | ENSP00000378063 | ENSP00000308895 | Schlafen family member 12; Belongs to the Schlafen family. Subgroup II subfamily. | Reduced folate transporter; Transporter that mediates the import of reduced folates and a subset of cyclic dinucleotides. Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate. Also able to mediate the import of antifolate drug methotrexate. Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP. Mechanistically, acts as an antiporter, which export of intracellular organic anions to facilitate uptake of [...] | 0.408 |
SLFN12 | SOWAHC | ENSP00000378063 | ENSP00000365830 | Schlafen family member 12; Belongs to the Schlafen family. Subgroup II subfamily. | Ankyrin repeat domain-containing protein SOWAHC; Sosondowah ankyrin repeat domain family member C; Belongs to the SOWAH family. | 0.485 |
SLFN12 | ZNF471 | ENSP00000378063 | ENSP00000309161 | Schlafen family member 12; Belongs to the Schlafen family. Subgroup II subfamily. | Zinc finger protein 471; May be involved in transcriptional regulation. | 0.458 |
SLFN12 | ZNF667 | ENSP00000378063 | ENSP00000439402 | Schlafen family member 12; Belongs to the Schlafen family. Subgroup II subfamily. | Zinc finger protein 667; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.446 |
SOWAHC | LIPG | ENSP00000365830 | ENSP00000261292 | Ankyrin repeat domain-containing protein SOWAHC; Sosondowah ankyrin repeat domain family member C; Belongs to the SOWAH family. | Endothelial lipase; Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin; Belongs to the AB hydrolase superfamily. Lipase family. | 0.464 |
SOWAHC | SLC19A1 | ENSP00000365830 | ENSP00000308895 | Ankyrin repeat domain-containing protein SOWAHC; Sosondowah ankyrin repeat domain family member C; Belongs to the SOWAH family. | Reduced folate transporter; Transporter that mediates the import of reduced folates and a subset of cyclic dinucleotides. Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate. Also able to mediate the import of antifolate drug methotrexate. Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP. Mechanistically, acts as an antiporter, which export of intracellular organic anions to facilitate uptake of [...] | 0.422 |
SOWAHC | SLFN12 | ENSP00000365830 | ENSP00000378063 | Ankyrin repeat domain-containing protein SOWAHC; Sosondowah ankyrin repeat domain family member C; Belongs to the SOWAH family. | Schlafen family member 12; Belongs to the Schlafen family. Subgroup II subfamily. | 0.485 |
ZNF471 | SLFN12 | ENSP00000309161 | ENSP00000378063 | Zinc finger protein 471; May be involved in transcriptional regulation. | Schlafen family member 12; Belongs to the Schlafen family. Subgroup II subfamily. | 0.458 |
ZNF667 | SLFN12 | ENSP00000439402 | ENSP00000378063 | Zinc finger protein 667; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Schlafen family member 12; Belongs to the Schlafen family. Subgroup II subfamily. | 0.446 |