node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACRV1 | SP9 | ENSP00000432816 | ENSP00000378418 | Acrosomal vesicle protein 1. | Transcription factor Sp9; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity). | 0.889 |
ACRV1 | TMEM176B | ENSP00000432816 | ENSP00000410269 | Acrosomal vesicle protein 1. | Transmembrane protein 176B; May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity). | 0.479 |
APOE | TMEM176B | ENSP00000252486 | ENSP00000410269 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | Transmembrane protein 176B; May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity). | 0.522 |
GIMAP4 | GIMAP5 | ENSP00000419545 | ENSP00000351473 | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | GTPase IMAP family member 5; Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the [...] | 0.898 |
GIMAP4 | GIMAP6 | ENSP00000419545 | ENSP00000479580 | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | GTPase, IMAP family member 6. | 0.907 |
GIMAP4 | GIMAP8 | ENSP00000419545 | ENSP00000305107 | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | GTPase IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections. | 0.911 |
GIMAP4 | TMEM176B | ENSP00000419545 | ENSP00000410269 | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | Transmembrane protein 176B; May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity). | 0.474 |
GIMAP4 | ZNF775 | ENSP00000419545 | ENSP00000330838 | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | Zinc finger protein 775; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.412 |
GIMAP5 | GIMAP4 | ENSP00000351473 | ENSP00000419545 | GTPase IMAP family member 5; Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the [...] | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | 0.898 |
GIMAP5 | GIMAP6 | ENSP00000351473 | ENSP00000479580 | GTPase IMAP family member 5; Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the [...] | GTPase, IMAP family member 6. | 0.829 |
GIMAP5 | GIMAP8 | ENSP00000351473 | ENSP00000305107 | GTPase IMAP family member 5; Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the [...] | GTPase IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections. | 0.825 |
GIMAP5 | TMEM176B | ENSP00000351473 | ENSP00000410269 | GTPase IMAP family member 5; Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the [...] | Transmembrane protein 176B; May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity). | 0.483 |
GIMAP5 | ZNF775 | ENSP00000351473 | ENSP00000330838 | GTPase IMAP family member 5; Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the [...] | Zinc finger protein 775; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.471 |
GIMAP6 | GIMAP4 | ENSP00000479580 | ENSP00000419545 | GTPase, IMAP family member 6. | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | 0.907 |
GIMAP6 | GIMAP5 | ENSP00000479580 | ENSP00000351473 | GTPase, IMAP family member 6. | GTPase IMAP family member 5; Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the [...] | 0.829 |
GIMAP6 | GIMAP8 | ENSP00000479580 | ENSP00000305107 | GTPase, IMAP family member 6. | GTPase IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections. | 0.913 |
GIMAP6 | TMEM176B | ENSP00000479580 | ENSP00000410269 | GTPase, IMAP family member 6. | Transmembrane protein 176B; May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity). | 0.509 |
GIMAP6 | ZNF775 | ENSP00000479580 | ENSP00000330838 | GTPase, IMAP family member 6. | Zinc finger protein 775; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.479 |
GIMAP8 | GIMAP4 | ENSP00000305107 | ENSP00000419545 | GTPase IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections. | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | 0.911 |
GIMAP8 | GIMAP5 | ENSP00000305107 | ENSP00000351473 | GTPase IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections. | GTPase IMAP family member 5; Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the [...] | 0.825 |