STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TGIF2LYHomeobox protein TGIF2LY; May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX; Belongs to the TALE/TGIF homeobox family. (185 aa)    
Predicted Functional Partners:
PABPC5
Polyadenylate-binding protein 5; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).
   
  
 0.931
PCDH11X
Protocadherin-11 X-linked; Potential calcium-dependent cell-adhesion protein.
      
 0.887
TGIF2LX
Homeobox protein TGIF2LX; May have a transcription role in testis.
  
 
 
0.871
TGFBI
Transforming growth factor-beta-induced protein ig-h3; Plays a role in cell adhesion. May play a role in cell-collagen interactions (By similarity).
   
  
 0.854
PCDH11Y
Protocadherin 11 Y-linked.
      
 0.703
VCY
Variable charge Y-linked.
   
  
 0.626
VCY1B
Testis-specific basic protein Y 1; May mediate a process in spermatogenesis or may play a role in sex ratio distortion; Belongs to the VCX/VCY family.
      
 0.621
TSPY1
Testis-specific Y-encoded protein 1; May be involved in sperm differentiation and proliferation.
   
  
 0.583
TSPY4
Testis specific protein Y-linked 4; Belongs to the nucleosome assembly protein (NAP) family.
      
 0.581
AMELY
Amelogenin, Y isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family.
   
  
 0.558
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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