node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C16orf78 | GOLGA8R | ENSP00000299191 | ENSP00000323217 | Uncharacterized protein C16orf78; Chromosome 16 open reading frame 78. | Golgin A8 family member R. | 0.411 |
CCDC142 | GOLGA8R | ENSP00000290418 | ENSP00000323217 | Coiled-coil domain containing 142. | Golgin A8 family member R. | 0.405 |
CCDC144NL | GOLGA8R | ENSP00000497867 | ENSP00000323217 | Putative coiled-coil domain-containing protein 144 N-terminal-like; CCDC144A N-terminal pseudogene; Belongs to the CCDC144 family. | Golgin A8 family member R. | 0.613 |
CDC42 | GOLGA8R | ENSP00000497733 | ENSP00000323217 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | Golgin A8 family member R. | 0.571 |
CDC42 | GOLGB1 | ENSP00000497733 | ENSP00000377275 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | Golgin subfamily B member 1; May participate in forming intercisternal cross-bridges of the Golgi complex. | 0.425 |
CDC42 | RHOD | ENSP00000497733 | ENSP00000308576 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | Rho-related GTP-binding protein RhoD; Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution; Belongs to the small GTPase superfamily. Rho family. | 0.494 |
GOLGA8R | C16orf78 | ENSP00000323217 | ENSP00000299191 | Golgin A8 family member R. | Uncharacterized protein C16orf78; Chromosome 16 open reading frame 78. | 0.411 |
GOLGA8R | CCDC142 | ENSP00000323217 | ENSP00000290418 | Golgin A8 family member R. | Coiled-coil domain containing 142. | 0.405 |
GOLGA8R | CCDC144NL | ENSP00000323217 | ENSP00000497867 | Golgin A8 family member R. | Putative coiled-coil domain-containing protein 144 N-terminal-like; CCDC144A N-terminal pseudogene; Belongs to the CCDC144 family. | 0.613 |
GOLGA8R | CDC42 | ENSP00000323217 | ENSP00000497733 | Golgin A8 family member R. | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | 0.571 |
GOLGA8R | GOLGB1 | ENSP00000323217 | ENSP00000377275 | Golgin A8 family member R. | Golgin subfamily B member 1; May participate in forming intercisternal cross-bridges of the Golgi complex. | 0.489 |
GOLGA8R | GOSR1 | ENSP00000323217 | ENSP00000225724 | Golgin A8 family member R. | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] | 0.459 |
GOLGA8R | MTMR10 | ENSP00000323217 | ENSP00000402537 | Golgin A8 family member R. | Myotubularin related protein 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | 0.428 |
GOLGA8R | RHOD | ENSP00000323217 | ENSP00000308576 | Golgin A8 family member R. | Rho-related GTP-binding protein RhoD; Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution; Belongs to the small GTPase superfamily. Rho family. | 0.563 |
GOLGA8R | STX5 | ENSP00000323217 | ENSP00000294179 | Golgin A8 family member R. | Syntaxin-5; Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter- connected structure of the Golgi apparatus. | 0.482 |
GOLGB1 | CDC42 | ENSP00000377275 | ENSP00000497733 | Golgin subfamily B member 1; May participate in forming intercisternal cross-bridges of the Golgi complex. | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-med [...] | 0.425 |
GOLGB1 | GOLGA8R | ENSP00000377275 | ENSP00000323217 | Golgin subfamily B member 1; May participate in forming intercisternal cross-bridges of the Golgi complex. | Golgin A8 family member R. | 0.489 |
GOLGB1 | GOSR1 | ENSP00000377275 | ENSP00000225724 | Golgin subfamily B member 1; May participate in forming intercisternal cross-bridges of the Golgi complex. | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] | 0.990 |
GOLGB1 | STX5 | ENSP00000377275 | ENSP00000294179 | Golgin subfamily B member 1; May participate in forming intercisternal cross-bridges of the Golgi complex. | Syntaxin-5; Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter- connected structure of the Golgi apparatus. | 0.988 |
GOSR1 | GOLGA8R | ENSP00000225724 | ENSP00000323217 | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] | Golgin A8 family member R. | 0.459 |