node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGO2 | GPRASP2 | ENSP00000220592 | ENSP00000437872 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | G-protein coupled receptor-associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors. | 0.522 |
ALMS1 | GPRASP2 | ENSP00000482968 | ENSP00000437872 | Alstrom syndrome protein 1; Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells. | G-protein coupled receptor-associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors. | 0.540 |
CTSG | GPRASP2 | ENSP00000216336 | ENSP00000437872 | Cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride. | G-protein coupled receptor-associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors. | 0.633 |
CTSG | TCF25 | ENSP00000216336 | ENSP00000263346 | Cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride. | Transcription factor 25; May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development. Belongs to the TCF25 family. | 0.607 |
GPRASP2 | AGO2 | ENSP00000437872 | ENSP00000220592 | G-protein coupled receptor-associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors. | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | 0.522 |
GPRASP2 | ALMS1 | ENSP00000437872 | ENSP00000482968 | G-protein coupled receptor-associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors. | Alstrom syndrome protein 1; Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells. | 0.540 |
GPRASP2 | CTSG | ENSP00000437872 | ENSP00000216336 | G-protein coupled receptor-associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors. | Cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride. | 0.633 |
GPRASP2 | GYS1 | ENSP00000437872 | ENSP00000317904 | G-protein coupled receptor-associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors. | Glycogen [starch] synthase, muscle; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. | 0.527 |
GPRASP2 | PIFO | ENSP00000437872 | ENSP00000358753 | G-protein coupled receptor-associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors. | Protein pitchfork; During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle- dependent manner. | 0.805 |
GPRASP2 | PPP1R3B | ENSP00000437872 | ENSP00000308318 | G-protein coupled receptor-associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors. | Protein phosphatase 1 regulatory subunit 3B; Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated gl [...] | 0.535 |
GPRASP2 | PYGB | ENSP00000437872 | ENSP00000216962 | G-protein coupled receptor-associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors. | Glycogen phosphorylase, brain form; Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | 0.541 |
GPRASP2 | PYGL | ENSP00000437872 | ENSP00000216392 | G-protein coupled receptor-associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors. | Glycogen phosphorylase, liver form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | 0.601 |
GPRASP2 | SMO | ENSP00000437872 | ENSP00000249373 | G-protein coupled receptor-associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors. | Smoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia. Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). | 0.609 |
GPRASP2 | TCF25 | ENSP00000437872 | ENSP00000263346 | G-protein coupled receptor-associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors. | Transcription factor 25; May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development. Belongs to the TCF25 family. | 0.994 |
GYS1 | GPRASP2 | ENSP00000317904 | ENSP00000437872 | Glycogen [starch] synthase, muscle; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. | G-protein coupled receptor-associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors. | 0.527 |
GYS1 | PPP1R3B | ENSP00000317904 | ENSP00000308318 | Glycogen [starch] synthase, muscle; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. | Protein phosphatase 1 regulatory subunit 3B; Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated gl [...] | 0.987 |
GYS1 | PYGB | ENSP00000317904 | ENSP00000216962 | Glycogen [starch] synthase, muscle; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. | Glycogen phosphorylase, brain form; Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | 0.956 |
GYS1 | PYGL | ENSP00000317904 | ENSP00000216392 | Glycogen [starch] synthase, muscle; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. | Glycogen phosphorylase, liver form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | 0.909 |
PIFO | GPRASP2 | ENSP00000358753 | ENSP00000437872 | Protein pitchfork; During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle- dependent manner. | G-protein coupled receptor-associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors. | 0.805 |
PIFO | SMO | ENSP00000358753 | ENSP00000249373 | Protein pitchfork; During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle- dependent manner. | Smoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia. Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). | 0.517 |