C7orf50 protein (human) - STRING interaction network

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C7orf50

Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50. (194 aa)

Predicted Functional Partners:

SURF6

0.751

MAK16

0.662

DNTTIP2

0.652

PUM3

0.648

DKC1

0.638

TMA16

0.635

EBNA1BP2

0.618

RRP15

0.597

NIFK

0.569

NOP53

0.566

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C7orf50	DKC1	ENSP00000380286	ENSP00000358563	Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50.	H/ACA ribonucleoprotein complex subunit DKC1; [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telom [...]	0.638
C7orf50	DNTTIP2	ENSP00000380286	ENSP00000411010	Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50.	Deoxynucleotidyltransferase terminal-interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein.	0.652
C7orf50	EBNA1BP2	ENSP00000380286	ENSP00000407323	Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50.	Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA.	0.618
C7orf50	MAK16	ENSP00000380286	ENSP00000353246	Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50.	MAK16 homolog.	0.662
C7orf50	NIFK	ENSP00000380286	ENSP00000285814	Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50.	Nucleolar protein interacting with the FHA domain of MKI67.	0.569
C7orf50	NOP53	ENSP00000380286	ENSP00000246802	Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50.	Ribosome biogenesis protein NOP53; Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription. Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 acti [...]	0.566
C7orf50	PUM3	ENSP00000380286	ENSP00000380982	Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50.	Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells (By similarity).	0.648
C7orf50	RRP15	ENSP00000380286	ENSP00000355899	Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50.	RRP15-like protein; Ribosomal RNA processing 15 homolog.	0.597
C7orf50	SURF6	ENSP00000380286	ENSP00000361092	Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50.	Surfeit locus protein 6; Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity).	0.751
C7orf50	TMA16	ENSP00000380286	ENSP00000351380	Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50.	Translation machinery associated 16 homolog.	0.635
DKC1	C7orf50	ENSP00000358563	ENSP00000380286	H/ACA ribonucleoprotein complex subunit DKC1; [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telom [...]	Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50.	0.638
DKC1	EBNA1BP2	ENSP00000358563	ENSP00000407323	H/ACA ribonucleoprotein complex subunit DKC1; [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telom [...]	Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA.	0.888
DKC1	MAK16	ENSP00000358563	ENSP00000353246	H/ACA ribonucleoprotein complex subunit DKC1; [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telom [...]	MAK16 homolog.	0.567
DKC1	NIFK	ENSP00000358563	ENSP00000285814	H/ACA ribonucleoprotein complex subunit DKC1; [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telom [...]	Nucleolar protein interacting with the FHA domain of MKI67.	0.959
DKC1	NOP53	ENSP00000358563	ENSP00000246802	H/ACA ribonucleoprotein complex subunit DKC1; [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telom [...]	Ribosome biogenesis protein NOP53; Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription. Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 acti [...]	0.906
DKC1	PUM3	ENSP00000358563	ENSP00000380982	H/ACA ribonucleoprotein complex subunit DKC1; [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telom [...]	Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells (By similarity).	0.928
DKC1	RRP15	ENSP00000358563	ENSP00000355899	H/ACA ribonucleoprotein complex subunit DKC1; [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telom [...]	RRP15-like protein; Ribosomal RNA processing 15 homolog.	0.416
DKC1	SURF6	ENSP00000358563	ENSP00000361092	H/ACA ribonucleoprotein complex subunit DKC1; [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telom [...]	Surfeit locus protein 6; Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity).	0.594
DNTTIP2	C7orf50	ENSP00000411010	ENSP00000380286	Deoxynucleotidyltransferase terminal-interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein.	Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50.	0.652
DNTTIP2	EBNA1BP2	ENSP00000411010	ENSP00000407323	Deoxynucleotidyltransferase terminal-interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein.	Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA.	0.846