STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RASGEF1CRas-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF). (466 aa)    
Predicted Functional Partners:
TMEM244
Transmembrane protein 244.
      
 0.525
RADIL
Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. Belongs to the RADIL family.
   
  
 0.504
ISOC1
Isochorismatase domain containing 1.
      
 0.499
MAP10
Microtubule-associated protein 10; Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis.
      
 0.490
C1orf115
Uncharacterized protein C1orf115; Chromosome 1 open reading frame 115.
      
 0.488
LYZL4
Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family.
   
  
 0.477
OR8H1
Olfactory receptor 8H1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.474
FAM13B
Protein FAM13B; Family with sequence similarity 13 member B.
      
 0.464
LIX1
Protein limb expression 1 homolog; Limb and CNS expressed 1; Belongs to the LIX1 family.
      
 0.457
ZNF23
Zinc finger protein 23; May be involved in transcriptional regulation. May have a role in embryonic development; Belongs to the krueppel C2H2-type zinc-finger protein family.
      
 0.423
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.